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Sarah C. Glover, DO

Sarah Glover_MCM_9647Sarah C. Glover, DO
Associate Professor of Medicine
Division of Gastroenterology, Hepatology, and Nutrition
Southeastern Center for Inflammatory Bowel Diseases/Affiliate Faculty Biomedical Engineering

University of Florida College of Medicine
Box 100214
Gainesville, Florida 32610-0214

Email: sarah.glover@medicine.ufl.edu

TEL: (352) 273-9400
FAX: (352) 627-9002

Dr. Glover grew up in the Pacific Northwest.  As an undergraduate, she attended Seattle Pacific University where she completed a chemistry degree.  During that time, she began her research career by working in the laboratory of Dr. Michael Gelb at the University of Washington.  She attended medical school at Chicago College of Osteopathic Medicine,  which is now part of Midwestern University where she was granted a Doctorate of Osteopathic Medicine in 1998.  Dr. Glover completed her residency and fellowship training at the University of Illinois at Chicago.  She was an assistant professor of medicine and bioengineering at UIC until 2010.  She joined the faculty at UF in early 2011.  Dr. Glover is an NIH funded investigator with clinic interests in allergic GI disorders and IBD.

Degree/Program

Institution

Field/Specialty

DO Midwestern University, CCOM Medicine
Residency University of Illinois at Chicago Internal Medicine
Fellowship University of Illinois at Chicago Gastroenterology

Academic Interests

Dr. Glover’s clinical practice is focused on inflammatory and allergic gastrointestinal disorders. In particular, she is interested in the role of food and environmental allergies in chronic abdominal pain and inflammatory bowel disease. She currently has one individual grant application and several collaborative grant applications that are pending to address these topics Dr. Glover’s research focuses on improving the understanding of how specific mechanical and luminal factors in the tumor microenvironment of colon cancer increase tumor cell invasion and metastasis. Currently, her NIH funded research is focused on how the mechanical features underlying malignant cells at the luminal interface influence tumor spread. The theory behind this project is that under normal circumstances cells in the colon, including colonic stem cells, follow a strict mechanical axis wherein they migrate from the bottom of the crypt to the top. In the setting of cancer, the axis is distorted and cells are permitted to move in both a two- and three-dimensional fashion. As such, significant changes occur in the topography underlying cells on the luminal side of a tumor. The data, thus far, suggests that these changes significantly alter mechanosensation and motility of cells and creates a pro-invasive cellular phenotype. Overall, Dr. Glover’s clinical and research interests are focused on understanding the role of gut microenvironment in both non-neoplastic and neoplastic gastrointestinal disorders.

Clinical Interests

  • Inflammatory Bowel Disease
  • Autoimmune Gastrointestinal Disorders
  • Eosinophilic Esophagitis
  • Eosinophilic Gastroenteritis
  • Eosinophilic Colitis
  • Mast Cell Activation Syndrome
  • Mastocytic Enterocolitis
  • Food and Environmental Allergy
  • GI disorders

Publications

  1. Glover, S.; de Carvalho, MS; Bayburt, T; Jonas, M.; Gelb, MH; and Others Translocation of the kDa Phospholipase A2 From Cytosol to the Nuclear Envelope in Rat Basophilic Leukemia Cells stimulated with Calcium lonophore or IgG Antigen. J. Biol. Chem.1995, June 23;270(25): 15359‑67.
  2. Glover S. Tretiakova MS, Carroll RE, Benya RV. Gastrin-releasing peptide receptor gene mutations in human colon cancer.   Mol Carcinog. 2003, 37:5-15.
  3. Matkowskyj, KA, Keller, K Glover, S Kornberg, L Tran Son Tay, R Benya, RV Expression of GRP and its receptor in well differentiated colon cancer cells correlates with the presence of focal adhesion kinase phosphorylated at tyrosine 397 and 407.  J. Histochem. Cytochem. 2003, 51:1041-1048.
  4. Matkowskyj KA, Glover S, Benya RV. Quantitative immunohistochemistry (Q-IHC): A novel algorithm for measuring cumulative signal strength and predicting receptor number. Microscopy & Analysis, 2004; 18: (issue #66) 5-6.
  5. S Glover, M Delaney, C Dematte, M. Frasco, L Kornberg, R Tran-Son-Tay, RV Benya.  Phosphorylation of Tyrosine 397 Critically Mediates Gastrin-Releasing Peptide’s Morphogenic Properties. J. Cell. Phys.. 2004,199:77-88.
  6. Matusiak, D. Glover, S. Nathaniel, R. Matkowskyj, K.A. Benya, R.V. Neuromedin B and Its Receptor are Mitogens in both Normal and Malignant Epithelial Cells Lining the Colon. AJP-Gastro. 2005, 288(4): G718-28.
  7. Glover, S. Nathaniel,, R. Shakir, L. Perrault, C. Anderson, R.K. Tran-Son-Tay,R.  and  Benya, R. V. Transient up-regulation of GRP and its receptor critically regulates Caco-2 cell motility during remodeling.  AJP-Gastro. 2005, 288(6): G1274-82.
  8. Anderson, RA. Shakir, L. Anderson, E. Glover S, Image Analysis of Extracellular Matrix Topography of Colon Cancer Cells. Microscopy & Analysis, July 2006: 5-7
  9. Vishnubhotla, R. and Sun, S. Huq, J.  Bulic, M. Ramesh, A. Guzamn, G, Cho, M. Glover, S.C. ROCK-II Mediates Colon Cancer Invasion Via Regulation of MMP-2 and 13 at the Site of Invadopodia As Revealed By Multiphoton Imaging. Lab Invest. 7(11):1149-58.
  10. Rapier,R. Huq,J. Vishnubhotla,R. Bulic,M. Perrault,CM .Metlushko,V. Cho,M. Tran Son Tay,R. Glover, SC. The Extracellular Matrix Microtopography Drives Critical Changes in Cellular Motility and Rho A Activity in Colon Cancer Cells.  Cancer Cell International. 2010 28;10:24..

Abstracts:

  1. Ece. A. Mutlu, Sarah C. Glover, Patrick M. Gillevet, Xavier Llor, Carline R. Quander, Masoumeh Sikaroodi         , Phillip Engen, Samuel Bracamonte, Ali Keshavarzian. Bacterial microbiota fingerprints are altered in colon cancer. Gastroenterology 2008: 134(4): A296.
  2. Sarah C. Glover, Marinka Bulic, Ramana V. Vishnubhotla, V. K. Viswanathan1, Michael Cho, Jennifer L. Roxas, Rebecca Mecum, Igor Titushkin A Loss of Symbiosis with Certain Strains of Commensal E. coli Leads to Increased Colon Cancer Invasion in an In Vitro Colon Cancer Model via activation of Rac and MMP-1. Gastroenterology 2008: 134 (4): A306.
  3. Sarah C. Glover, Ravi J. Patel, Grace Guzman, Elizabeth L. Wiley, Ian Coelho.  To Biopsy or Not to Biopsy in Chronic Constipation?  A Possible Role for Eosinophils in this Irritating Condition.  Gastroenterology 2009: 136 (5): A284.
  4. Sarah C. Glover, Chinmay Chauhan, Crystal L. Foster, Shruthi Bharadwaj, Ramana V. Vishnubhotla, Victor Nekrasov. Polyethylene Glycol (PEG) Prevents Against the Pro-Invasive Effects of Both Commensal and Pathogenic E. coli and May Increase Chemoresponsiveness of Colon Cancer Cells By Increasing Proliferation.  Gastroenterology 2009: 136 (5 Supp 1): A321.
  5. Sarah C. Glover, Victor Nekrasov, Ramana V. Vishnubhotla, Shruthi Bharadwaj, Crystal L. Foster. Commensal E. coli Strains Have the Ability to Alter the ECM Topography Independent of Colonic Epithelial Cells.  Gastroenterology 2009: 136 (5 Supp 1): A573.
  6. Ramana V. Vishnubhotla, Shruthi Bharadwaj, Victor Nekrasov, Sarah C. Glover. Colon Cancer and Rho Kinase: Is Rock-II Really the Most Active Rock? Gastroenterology 2010: 138 (5 Supp 1): S-736.
  7. Victor Nekrasov, Igor Titushkin, Michael Cho, Sarah C. Glover. In Vitro and In Vivo Evidence in Support of Differentiation of Colon Cancer Stem Cells Into Adipocyte-Like Cells.  Gastroenterology 2010: 138 (5 Supp 1): S-570.
  8. S. Glover, N.R. Patel, P.K. Muniyappa. Gastrointestinal Mastocytosis: An Unexplored Etiology in Chronic Abdominal Pain and GI Dysmotility.  Journal of Allergy and Clinical Immunology 127, (2, Supp) AB252.

Please click here for a list of Dr. Glover’s industry relationships.

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