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Immunosuppression (Medications)

GENERAL CLASS GENERIC NAME BRAND NAME SIDE EFFECTS
Corticosteroids Prednisone Solu-Medrol,
Decadron,
Deltasone
High blood sugar
High blood pressure
High Cholesterol
Mood changes
Insomnia
Water Retention
Calcineurin
Inhibitors
Tacrolimus(FK 506) Prograf High blood sugar
High blood pressure
High Cholesterol
Kidney toxicity
Neuro toxicity
Headaches
Tremors
High potassium
Low magnesium
  Cyclosporine Sandimmune,
Neoral,
Gengraf
High blood sugar
High blood pressure
High Cholesterol
Kidney toxicity
Headaches
Tremors
Seizures
High Potassium
Antimetabolites Azathioprine (AZA) Imuran Low blood counts
Stomach Upset
Rash
  Mycophenolate
Mofetil
Cellcept Diarrhea
Nausea
Vomiting
Stomach Ulcers
Low WBC
Polyclonal Abs Antithymocyte
globulin
Thymoglobulin
ATGAM
Usually less severe
than OKT3
Anti-CD3
monoclonal Abs
Muromonab-CD3 OKT3 Flu-like symptoms
Fever
Chills
Headache
Diarrhea
Myalgia
Pulmonary edema
Seizures
Increase risk of
infections, meningitis
Anti-IL-2 receptor monoclonal
Abs
Daclizumab Zenapax  
TOR inhibitors Sirolimus or
Rapamycin
Rapamune High Cholesterol and lipids
Low blood counts
Diarrhea
Mouth Ulcers