Jobin Research Lab


 

Jobin Lab Research Statement

The Jobin Laboratory is interested in bacteria/host interactions and ensuring innate/immunological responses during health and diseases. The intestine poses an interesting conundrum – it must peacefully cohabit with a sea of microorganism (~100 trillion), but swiftly respond to the presence of pathogenic microorganisms that threaten its integrity. A major clinical consequence of deregulated bacteria/host interaction in the intestine is the development of inflammatory bowel diseases (IBD) and colorectal cancer (CRC). Using mice and zebrafish housed in germ-free and gnotobiotic conditions, the Jobin’s laboratory studies the contribution of bacteria in protecting or exacerbating development of colitis and colorectal cancer using different techniques (next-generation sequencing, microbial gene mutations, microbial RNA-sequence, etc.).  A number of questions are actively pursued by our laboratory including:

  • Which microorganisms protect or promote intestinal pathologies?
  • What microbial-derived activities are responsible for these differential host responses?
  • How microorganisms biotransform dietary components to influence development of intestinal pathologies?
  • Which mechanisms are implicated in beneficial host-microorganism interaction and what disrupt this peaceful dialogue?
  • How microorganisms influence development of extra-intestinal cancer?
  • What is the relationship between microorganisms and host response to therapeutic intervention?

Lab Personnel 

Christian Jobin, PhD
Professor of Medicine
Principal Investigator

Josee Gauthier

Scientific Lab Manager

Michael DoughteryMichael Doughtery

Lab Technician

 

Rachel Newsome 

Lab Technician

Zhen He

Postdoctoral Associate 

Research: Role of cytolethal distending toxin-carry bacteria in development of colitis-associated cancer.

Qin Yu

Graduate Student 

Christina Ohland

Postdoctoral Associate 

Research: Role of bacteria in biotransformation of dietary polyphenols and impact on colorectal cancer.

Jillian Pope

Postdoctoral Associate

Research: Interplay between neonate bacteria and host-derived innate signaling in development of colitis-associated cancer.

Sarah Tomkovich 

Biological Scientist

Research: Functional role of human-derived intestinal bacteria in colorectal cancer.

Ye Yang

Postdoctoral Associate 

Research: Impact of host signaling on microbial activities in the development of colitis-associated colorectal cancer


Past Members

Danielle Ferraguti

Pediatric Gastroenterology Fellow

Research: Influence of growth conditions on microbial carcinogenic activities

Velmurugan Ganesan

Postdoctoral Associate

Research: Role of hydrogen sulfite producing bacteria in development of colitis-associated cancer


Lab Activities 

Check out recent lab outings and notable achievements from the Jobin Lab.