Jobin Research Lab


 

Jobin Lab Research Statement

The Jobin Laboratory is interested in bacteria/host interactions and ensuring innate/immunological responses during health and diseases. The intestine poses an interesting conundrum – it must peacefully cohabit with a sea of microorganism (~100 trillion), but swiftly respond to the presence of pathogenic microorganisms that threaten its integrity. A major clinical consequence of deregulated bacteria/host interaction in the intestine is the development of inflammatory bowel diseases (IBD) and colorectal cancer (CRC). Using mice and zebrafish housed in germ-free and gnotobiotic conditions, the Jobin’s laboratory studies the contribution of bacteria in protecting or exacerbating development of colitis and colorectal cancer using different techniques (next-generation sequencing, microbial gene mutations, microbial RNA-sequence, etc.).  A number of questions are actively pursued by our laboratory including:

  • Which microorganisms protect or promote intestinal pathologies?
  • What microbial-derived activities are responsible for these differential host responses?
  • How microorganisms biotransform dietary components to influence development of intestinal pathologies?
  • Which mechanisms are implicated in beneficial host-microorganism interaction and what disrupt this peaceful dialogue?
  • How microorganisms influence development of extra-intestinal cancer?
  • What is the relationship between microorganisms and host response to therapeutic intervention?

Lab Personnel 

Christian Jobin, PhD
Professor of Medicine
Principal Investigator

 

Danielle Ferraguti

Pediatric Gastroenterology Fellow

Research: Influence of growth conditions on microbial carcinogenic activities

Vel Ganesan

Postdoctoral Associate

Research: Role of hydrogen sulfite producing bacteria in development of colitis-associated cancer

Josee Gauthier

Scientific Lab Manager

Zhen He

Postdoctoral Associate 

Research: Role of cytolethal distending toxin-carry bacteria in development of colitis-associated cancer.

Rachel Newsome 

Lab Technician

Christina Ohland

Postdoctoral Associate 

Research: Role of bacteria in biotransformation of dietary polyphenols and impact on colorectal cancer.

Jillian Pope

Postdoctoral Associate

Research: Interplay between neonate bacteria and host-derived innate signaling in development of colitis-associated cancer.

Sarah Tomkovich 

Biological Scientist

Research: Functional role of human-derived intestinal bacteria in colorectal cancer.

Ye Yang

Postdoctoral Associate 

Research: Impact of host signaling on microbial activities in the development of colitis-associated colorectal cancer


Lab Activities 

Check out recent lab outings and notable achievements from the Jobin Lab.