Jobin Research Lab

The Jobin Laboratory is interested in bacteria/host interactions and ensuring innate/immunological responses during health and diseases. The intestine poses an interesting conundrum – it must peacefully cohabit with a sea of microorganisms (~100 trillion) but swiftly respond to the presence of pathogenic microorganisms that threaten its integrity. A major clinical consequence of deregulated bacteria/host interaction in the intestine is the development of inflammatory bowel diseases (IBD) and colorectal cancer (CRC).

Using mice and zebrafish housed in germ-free and gnotobiotic conditions, the Jobin’s laboratory studies the contribution of bacteria in protecting or exacerbating development of colitis and colorectal cancer using different techniques (next-generation sequencing, microbial gene mutations, microbial RNA-sequence, etc.). A number of questions are actively pursued by our laboratory, including:

  • Which microorganisms protect or promote intestinal pathologies?
  • What microbial-derived activities are responsible for these differential host responses?
  • How microorganisms biotransform dietary components to influence development of intestinal pathologies?
  • Which mechanisms are implicated in beneficial host-microorganism interaction and what disrupts this peaceful dialogue?
  • How microorganisms influence development of extra-intestinal cancer?
  • What is the relationship between microorganisms and host response to therapeutic intervention?

Lab Personnel

Christian Jobin

Christian Jobin Ph.D.

Professor Of Medicine; Principal Investigator
Josee Gauthier

Josee Gauthier

Laboratory Manager
Mark J Beveridge

Mark J Beveridge

Senior Biological Scientist
Yoshitaka Murota

Yoshitaka Murota

Postdoctoral Associate
Rachel C Newsome

Rachel C Newsome

Graduate Student
Rui Xiao

Rui Xiao Ph.D.

Assistant Professor
Qin Yu

Qin Yu

Graduate Student

Past Members


Danielle Ferraguti
Pediatric GI Fellow
Velmurugan Ganesan
Postdoctoral Associate
Zhen Ye
Postdoctoral Associate
Geun Shik Lee
Visiting Scholar
Yangsoon Lee
Visiting Scientist
Sarah Tomkovich
Postdoctoral Associate
Abeer Dagra
Undergrad Research Asst.
Isabel Lopera
Undergrad Research Asst.

Lab activities

Recent lab outings and notable achievements.