Jobin Research Lab

Jobin Lab Group  Jobin Lab Research Statement

The Jobin Laboratory is interested in bacteria/host interactions and ensuring innate/immunological responses during health and diseases. The intestine poses an interesting conundrum – it must peacefully cohabit with a sea of microorganism (~100 trillion), but swiftly respond to the presence of pathogenic microorganisms that threaten its integrity. A major clinical consequence of deregulated bacteria/host interaction in the intestine is the development of inflammatory bowel diseases (IBD) and colorectal cancer (CRC). Using mice and zebrafish housed in germ-free and gnotobiotic conditions, the Jobin’s laboratory studies the contribution of bacteria in protecting or exacerbating development of colitis and colorectal cancer using different techniques (next-generation sequencing, microbial gene mutations, microbial RNA-sequence, etc.).  A number of questions are actively pursued by our laboratory including:

  • Which microorganisms protect or promote intestinal pathologies?
  • What microbial-derived activities are responsible for these differential host responses?
  • How microorganisms biotransform dietary components to influence development of intestinal pathologies?
  • Which mechanisms are implicated in beneficial host-microorganism interaction and what disrupt this peaceful dialogue?
  • How microorganisms influence development of extra-intestinal cancer?
  • What is the relationship between microorganisms and host response to therapeutic intervention?

Lab Personnel 

Christian Jobin, PhD

Professor of Medicine
Principal Investigator

Josee Gauthier

Scientific Lab Manager

Mark BeveridgeMark J. Beveridge

Senior Biological Scientist

Michael DoughteryMichael Doughtery

Lab Technician

Rui Xiao Rui Xiao

Lab Technician

Christina Ohland

Postdoctoral Associate 

Research: Role of bacteria in biotransformation of dietary polyphenols and impact on colorectal cancer.

Yoshitaka MurotaYoshitaka Murota

Postdoctoral Associate

Research: Study the activities of a cancer-promoting bacteria in colorectal cancer.

Jillian Pope

Postdoctoral Associate

Research: Interplay between neonate bacteria and host-derived innate signaling in development of colitis-associated cancer.

Ye Yang

Postdoctoral Associate 

Research: Impact of host signaling on microbial activities in the development of colitis-associated colorectal cancer

Rachel NewsomeRachel Newsome 

Graduate Student

Qin Yu

Graduate Student 

Claudia Mercado RodriguezClaudia Mercado Rodriguez

Graduate Student

Nicky CraigNicky Craig

Visiting Research Scholar

Past Members

Danielle Ferraguti

Pediatric Gastroenterology Fellow

Research: Influence of growth conditions on microbial carcinogenic activities

Velmurugan Ganesan

Postdoctoral Associate

Research: Role of hydrogen sulfite producing bacteria in development of colitis-associated cancer

 Zhen He

Postdoctoral Associate 

Gastrointestinal Surgeon
Sixth Affiliate Hospital
Sun Yat-sen University, China 


Geun Shik Lee

Geun Shik Lee 

Visiting Scholar 

Yangsoon Lee

Yangsoon Lee

Visiting Scientist

Sarah Tomkovich 

Postdoctoral Associate

Abeer DagraAbeer Dagra

Undergraduate Research Assistant 

Isabel LoperaIsabel Lopera

Undergraduate Research Assistant 

Lab Activities 

Check out recent lab outings and notable achievements from the Jobin Lab.