Michael W Dougherty

Michael W Dougherty,

Graduate Student

Department: MD-GASTROENTEROLOGY
Business Phone: (954) 648-2380

Accomplishments

Graduate Student Symposia Travel Grant
2015 · Society for Vector Ecology
2nd Place Medical
2014 · Urban & Veterinary Entomology Student Competition for the President’s Prize, National Meeting of the Entomological Society of America
Esther Wadsworth Wheeler Award for Graduate Research
2013 · University of North Dakota

Research Profile

My background is in the ecology of arthropod borne bacterial pathogens, specifically the tick vector Ixodes scapularis and the Lyme disease agent, Borrelia burgdorferi. My master’s thesis focused on the distribution and population dynamics of B. burgdorferi in the upper Midwest, and specifically investigated the role for non-traditional vertebrate reservoirs of Lyme disease. Since joining the Jobin lab, my focus has switched to the various roles of the gut microbiome in gastrointestinal disorders. I am interested in the applications of mini-gut (organoid) cultures as a model for various diseases of the gut. Currently I am involved in two projects: (1) the effects of Campylobacter jejuni and the cytolethal distending toxin (Cdt) on colorectal cancer development, and (2) the roles of microbial metabolites on the development of necrotizing enterocolitis in pre-term infants. Applying in vitro organoid models to these research questions allows a high-throughput, nuanced method of investigating relationships between microbes and disease pathways.

Open Researcher and Contributor ID (ORCID)

0000-0002-3774-7912

Publications

2022
Thymidylate synthase accelerates Men1-mediated pancreatic tumor progression and reduces survival
JCI Insight. 7(19) [DOI] 10.1172/jci.insight.147417. [PMID] 36048542.
2021
Mitochondrial transcription factor A in RORγt+ lymphocytes regulate small intestine homeostasis and metabolism
Nature Communications. 12(1) [DOI] 10.1038/s41467-021-24755-9. [PMID] 34294718.
2021
Shining a Light on Colibactin Biology
Toxins. 13(5) [DOI] 10.3390/toxins13050346. [PMID] 34065799.
2020
Gut microbiota maturation during early human life induces enterocyte proliferation via microbial metabolites.
BMC microbiology. 20(1) [DOI] 10.1186/s12866-020-01892-7. [PMID] 32652929.
2019
Campylobacter jejuni promotes colorectal tumorigenesis through the action of cytolethal distending toxin.
Gut. 68(2):289-300 [DOI] 10.1136/gutjnl-2018-317200. [PMID] 30377189.
2014
Survey of ticks (Acari: Ixodidae) and tick-borne pathogens in North Dakota.
Journal of medical entomology. 51(5):1087-90 [PMID] 25276942.

Education

Master of Science
2015 · University of North Dakota
Bachelor of Science
2012 · Florida State University

Contact Details

Phones:
Business:
(954) 648-2380
Addresses:
Business Mailing:
PO Box 100214
GAINESVILLE FL 32610