Christian Jobin, Ph.D.
UFHCC Co-leader Immuno-Oncology and Microbiome program, UF Health Cancer Center, Gatorade Trust and Distinguished Professor of Medicine, University of Florida
About Christian Jobin
Additional Positions:
UFHCC Co-leader Immuno-Oncology and Microbiome program
2025 – Current
·
UF Health Cancer Center
Gatorade Trust and Distinguished Professor of Medicine
2025 – Current
·
University of Florida
Accomplishments
Associate Editor
2017-2020
·
Microbiome
Chair study section for Program Project Grant exploring the metabolic, epigenetic and microbiome drivers of inflammation driven malignancy
2017
·
Terry Fox Research Institute
Permanent Member
2015-2020
·
NIH GMPB
UF Senior Faculty Excellence in Research Award
2015
·
University of Florida
Study Section Memberships – Advisory Board
2014-2016
·
CIHR Institute Advisory Board of Infection and Immunity
Study Section Memberships – Advisory Board
2014-2015
·
AICR
Study Section Memberships -Advisory Board
2014-2015
·
American Society for Cancer
Study Section Memberships – Advisory Board
2013-2020
·
NIH NCI Chair ZRG1 DKUS-D: Role of the Microflora in the Etiology of Gastrointestinal Cancer
Study Section Memberships – Advisory Board
2011-2020
·
Ad Hoc NIH Gastrointestinal Mucosal Pathobiology (GMBP)
Study Section Memberships – Advisory Board
2010-2013
·
Canadian Institutes of Health Research, Vanier Canada Graduate Scholarships
Admission Committee
2009-2012
·
UNC Biological and Biomedical Sciences Program
IBD: Associate Editor
2008-2016
·
Cell Biology/Biochemistry/Molecular Biology
Study Section Memberships – Advisory Board
2008-2011
·
CCFA Study section (Fellowship and Career Awards)
Study Section
2007-2020
·
NIH Tumor Microenvironment (TME)
IBD: Section Editor
2007-2008
·
Cell Biology/Biochemistry/Molecular Biology
Editorial Board Member
2005-2010
·
Gastroenterology
Fireman Young Scientist Basic Research Award
2005
·
American Gastroenterological Association
Junior Faculty Development Award
2005
·
UNC
University Research Council Award
2004
·
Mucosal Immunology Society
Study Section Memberships – Advisory Board
2003-2007
·
Canadian Institutes of Health Research, Experimental Medicine
Study Section Memberships – Advisory Board
2002-2020
·
Ad Hoc NIH Special Emphasis Panel NIDDK
Editorial Board Member
2001-2009
·
American Journal of Physiology
Anne Ferguson Award
1999
·
Mucosal Immunology Society
Young investigator travel award
1999
·
Mucosal Immunology
Career Development Award
1998-1999
·
CCFA
CCFA Young IBD Investigator Award
1998
·
“Regulation and modulation of the IkB/NF-kB transcriptional system in intestinal epithelial cells”
University Research Council Award
1998
·
University Research Council Award
CCFA young investigator travel award
1996
·
“Immune/non-immune cell interaction in intestinal inflammation” meeting in Florida
CCFA young investigator travel award
1995
·
“Interactions between genetics and microbiology in inflammatory bowel disease” meeting in South Carolina
Ph.D fellowships
1991-1993
·
Laval University
Ph.D fellowship
1990-1991
·
Hôpital Saint-François d’Assise
Teaching Profile
Courses Taught
2018-2025
GMS6065 Fundamentals of Cancer Biology
2016-2019
GMS6001 Fundamentals of Biomedical Sciences I
2018
GMS7979 Advanced Research
2018
GMS7980 Research for Doctoral Dissertation
2013
VME6934 Topics in Veterinary Medical Sciences
Publications
Academic Articles
2025
Bioreactor Assembly for Continuous Culture of Complex Fecal Communities.
Journal of visualized experiments : JoVE.
(218)
[DOI] 10.3791/68035.
[PMID] 40354237.
2025
Colibactin Exerts Androgen-dependent and -independent Effects on Prostate Cancer.
European urology oncology.
8(3):716-730
[DOI] 10.1016/j.euo.2024.10.015.
[PMID] 39547899.
2025
Dietary fibre counters the oncogenic potential of colibactin-producing Escherichia coli in colorectal cancer
Nature Microbiology.
10(4):855-870
[DOI] 10.1038/s41564-025-01938-4.
2025
DUOX2 activation drives bacterial translocation and subclinical inflammation in IBD-associated dysbiosis
Gut.
gutjnl-2024
[DOI] 10.1136/gutjnl-2024-334346.
2025
Emerging Roles of Modern Lifestyle Factors in Microbiome Stability and Functionality
Current Clinical Microbiology Reports.
12(1)
[DOI] 10.1007/s40588-025-00242-3.
2025
Genome-scale CRISPR/Cas9 screening reveals the role of PSMD4 in colibactin-mediated cell cycle arrest
mSphere.
10(3)
[DOI] 10.1128/msphere.00692-24.
[PMID] 39918307.
2025
Preparation and Maintenance of Bioexclusion IsoPositive Cage Experiment for Human Fecal Transplantation into Germ-Free Mice.
Journal of visualized experiments : JoVE.
(216)
[DOI] 10.3791/68029.
[PMID] 40095949.
2024
Antibiotic-Induced Gut Microbiota Dysbiosis Modulates Host Transcriptome and m6A Epitranscriptome via Bile Acid Metabolism.
Advanced science (Weinheim, Baden-Wurttemberg, Germany).
11(28)
[DOI] 10.1002/advs.202307981.
[PMID] 38713722.
2024
Association between gut microbiota and CpG island methylator phenotype in colorectal cancer
Gut Microbes.
16(1)
[DOI] 10.1080/19490976.2024.2363012.
[PMID] 38860458.
2024
Campylobacter jejuni-derived cytolethal distending toxin promotes colorectal cancer metastasis
Cell Host & Microbe.
32(12):2080-2091.e6
[DOI] 10.1016/j.chom.2024.11.006.
2024
Chemotherapy-induced microbiota exacerbates the toxicity of chemotherapy through the suppression of interleukin-10 from macrophages.
Gut microbes.
16(1)
[DOI] 10.1080/19490976.2024.2319511.
[PMID] 38400752.
2024
Correlation between intestinal microbiota and urolithin metabolism in a human walnut dietary intervention.
BMC microbiology.
24(1)
[DOI] 10.1186/s12866-024-03626-5.
[PMID] 39548408.
2024
Effect of Routine Gastric Residual Aspiration on the Preterm Infant Fecal Microbiome.
American journal of perinatology.
41(S 01):e212-e220
[DOI] 10.1055/a-1877-6306.
[PMID] 35709728.
2024
Metabolic immaturity and breastmilk bile acid metabolites are central determinants of heightened newborn vulnerability to norovirus diarrhea.
Cell host & microbe.
32(9):1488-1501.e5
[DOI] 10.1016/j.chom.2024.08.003.
[PMID] 39214086.
2023
Hematopoietic-specific heterozygous loss of Dnmt3a exacerbates colitis-associated colon cancer
Journal of Experimental Medicine.
220(11)
[DOI] 10.1084/jem.20230011.
[PMID] 37615936.
2023
Intestinal bacteria and colorectal cancer: etiology and treatment
Gut Microbes.
15(1)
[DOI] 10.1080/19490976.2023.2185028.
[PMID] 36927206.
2023
Microbiota Influences on Hematopoiesis and Blood Cancers: New Horizons?
Blood Cancer Discovery.
4(4):267-275
[DOI] 10.1158/2643-3230.bcd-22-0172.
2023
Non-pathogenic microbiota accelerate age-related CpG Island methylation in colonic mucosa
Epigenetics.
18(1)
[DOI] 10.1080/15592294.2022.2160568.
[PMID] 36572998.
2023
Prevalence of genotoxic bacteria in men undergoing biopsy for prostate cancer.
The Prostate.
83(7):663-669
[DOI] 10.1002/pros.24500.
[PMID] 36842100.
2023
Skin microbiome sampling in the preterm neonate.
Pediatric dermatology.
40(1):129-131
[DOI] 10.1111/pde.15158.
[PMID] 36385397.
2023
The microbial genotoxin colibactin exacerbates mismatch repair mutations in colorectal tumors.
Neoplasia (New York, N.Y.).
43
[DOI] 10.1016/j.neo.2023.100918.
[PMID] 37499275.
2023
Western diet influences on microbiome and carcinogenesis.
Seminars in immunology.
67
[DOI] 10.1016/j.smim.2023.101756.
[PMID] 37018910.
2022
Bacteriophage-mediated manipulations of microbiota in gastrointestinal diseases.
Frontiers in microbiology.
13
[DOI] 10.3389/fmicb.2022.1055427.
[PMID] 36466675.
2022
Finding clues in unexpected places: detection of pancreatic cancer through the faecal microbiome
Gut.
71(7):1247-1248
[DOI] 10.1136/gutjnl-2021-326710.
[PMID] 35260443.
2022
Fusobacterium is enriched in oral cancer and promotes induction of programmed death-ligand 1 (PD-L1).
Neoplasia (New York, N.Y.).
31
[DOI] 10.1016/j.neo.2022.100813.
[PMID] 35834946.
2022
Group 3 innate lymphoid cell pyroptosis represents a host defence mechanism against Salmonella infection
Nature Microbiology.
7(7):1087-1099
[DOI] 10.1038/s41564-022-01142-8.
[PMID] 35668113.
2022
Gut Microbiota as a Novel Tool to Dissect the Complex Structures of Black Tea Polymers.
Journal of agricultural and food chemistry.
70(16):5005-5014
[DOI] 10.1021/acs.jafc.2c00995.
[PMID] 35420414.
2022
Human Colon Cancer–Derived Clostridioides difficile Strains Drive Colonic Tumorigenesis in Mice
Cancer Discovery.
12(8):1873-1885
[DOI] 10.1158/2159-8290.cd-21-1273.
2022
Interaction of bacterial genera associated with therapeutic response to immune checkpoint PD-1 blockade in a United States cohort
Genome Medicine.
14(1)
[DOI] 10.1186/s13073-022-01037-7.
[PMID] 35346337.
2022
Intestinal microbiota modulates pancreatic carcinogenesis through intratumoral natural killer cells
Gut Microbes.
14(1)
[DOI] 10.1080/19490976.2022.2112881.
[PMID] 35980869.
2022
MarZIC: A Marginal Mediation Model for Zero-Inflated Compositional Mediators with Applications to Microbiome Data
Genes.
13(6)
[DOI] 10.3390/genes13061049.
[PMID] 35741811.
2022
NTPDase8 protects mice from intestinal inflammation by limiting P2Y6 receptor activation: identification of a new pathway of inflammation for the potential treatment of IBD
Gut.
71(1):43-54
[DOI] 10.1136/gutjnl-2020-320937.
2022
The microbiome, gastrointestinal cancer, and immunotherapy
Journal of Gastroenterology and Hepatology.
37(2):263-272
[DOI] 10.1111/jgh.15742.
[PMID] 34820895.
2022
Thymidylate synthase accelerates Men1-mediated pancreatic tumor progression and reduces survival
JCI Insight.
7(19)
[DOI] 10.1172/jci.insight.147417.
[PMID] 36048542.
2021
Avenanthramide Metabotype from Whole-Grain Oat Intake is Influenced by Faecalibacterium prausnitzii in Healthy Adults.
The Journal of nutrition.
151(6):1426-1435
[DOI] 10.1093/jn/nxab006.
[PMID] 33694368.
2021
Bacteria break barrier to promote metastasis.
Cancer cell.
39(5):598-600
[DOI] 10.1016/j.ccell.2021.03.009.
[PMID] 33891891.
2021
Bacterial Swarmers Enriched During Intestinal Stress Ameliorate Damage.
Gastroenterology.
161(1):211-224
[DOI] 10.1053/j.gastro.2021.03.017.
[PMID] 33741315.
2021
Black Tea Theaflavin Detoxifies Metabolic Toxins in the Intestinal Tract of Mice.
Molecular nutrition & food research.
65(4)
[DOI] 10.1002/mnfr.202000887.
[PMID] 33381889.
2021
Commensal bacteria promote endocrine resistance in prostate cancer through androgen biosynthesis
Science.
374(6564):216-224
[DOI] 10.1126/science.abf8403.
2021
Far reach of Fusobacterium nucleatum in cancer metastasis
Gut.
70(8):1427-1429
[DOI] 10.1136/gutjnl-2020-323496.
2021
Gut Microbiota Dysbiosis Associated with Persistent Fatigue in Hematopoietic Cell Transplantation Survivors.
Transplantation and cellular therapy.
27(6):498.e1-498.e8
[DOI] 10.1016/j.jtct.2021.02.017.
[PMID] 33775619.
2021
IFAA: Robust Association Identification and Inference for Absolute Abundance in Microbiome Analyses.
Journal of the American Statistical Association.
116(536):1595-1608
[DOI] 10.1080/01621459.2020.1860770.
[PMID] 35241863.
2021
Implications of the microbiome in the development and treatment of pancreatic cancer: Thinking outside of the box by looking inside the gut.
Neoplasia (New York, N.Y.).
23(2):246-256
[DOI] 10.1016/j.neo.2020.12.008.
[PMID] 33418277.
2021
Increased ACE2 Levels and Mortality Risk of Patients With COVID-19 on Proton Pump Inhibitor Therapy.
The American journal of gastroenterology.
116(8):1638-1645
[DOI] 10.14309/ajg.0000000000001311.
[PMID] 34047305.
2021
Microbiome-Derived Liquid Biopsy: New Hope for Cancer Screening?
Clinical chemistry.
67(3):463-465
[DOI] 10.1093/clinchem/hvaa240.
[PMID] 33277898.
2021
Microbiota in mesenteric adipose tissue from Crohn’s disease promote colitis in mice.
Microbiome.
9(1)
[DOI] 10.1186/s40168-021-01178-8.
[PMID] 34814945.
2021
Microbiota phylogenic analysis revealed decreased abundance of Faecalibacterium prausnitzii, an anti-inflammatory commensal bacterium, in patients with chronic graft-versus-host disease.
Hematology/oncology and stem cell therapy.
14(3):263-265
[DOI] 10.1016/j.hemonc.2021.03.004.
[PMID] 33785388.
2021
Mitochondrial transcription factor A in RORγt+ lymphocytes regulate small intestine homeostasis and metabolism
Nature Communications.
12(1)
[DOI] 10.1038/s41467-021-24755-9.
[PMID] 34294718.
2021
Shining a Light on Colibactin Biology
Toxins.
13(5)
[DOI] 10.3390/toxins13050346.
[PMID] 34065799.
2021
The gut microbiome of COVID-19 recovered patients returns to uninfected status in a minority-dominated United States cohort.
Gut microbes.
13(1):1-15
[DOI] 10.1080/19490976.2021.1926840.
[PMID] 34100340.
2020
A mutational signature that can be made by a bacterium arises in human colon cancer.
Nature.
580(7802):194-195
[DOI] 10.1038/d41586-020-00818-7.
[PMID] 32203380.
2020
Amending microbiota by targeting intestinal inflammation with TNF blockade attenuates development of colorectal cancer
Nature Cancer.
1(7):723-734
[DOI] 10.1038/s43018-020-0078-7.
[PMID] 33768208.
2020
Baseline Gut Microbiota Composition Is Associated with Major Infections Early after Hematopoietic Cell Transplantation.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation.
26(11):2001-2010
[DOI] 10.1016/j.bbmt.2020.07.023.
[PMID] 32717434.
2020
Characterization of the bacterial microbiome among free-ranging bottlenose dolphins (Tursiops truncatus).
Heliyon.
6(6)
[DOI] 10.1016/j.heliyon.2020.e03944.
[PMID] 32577542.
2020
Dietary iron variably modulates assembly of the intestinal microbiota in colitis-resistant and colitis-susceptible mice.
Gut microbes.
11(1):32-50
[DOI] 10.1080/19490976.2019.1599794.
[PMID] 31179826.
2020
Gut microbiota maturation during early human life induces enterocyte proliferation via microbial metabolites
BMC Microbiology.
20(1)
[DOI] 10.1186/s12866-020-01892-7.
[PMID] 32652929.
2020
Human Colon Mucosal Biofilms and Murine Host Communicate via Altered mRNA and microRNA Expression during Cancer.
mSystems.
5(1)
[DOI] 10.1128/mSystems.00451-19.
[PMID] 31937674.
2020
Microbiota in pancreatic health and disease: the next frontier in microbiome research.
Nature reviews. Gastroenterology & hepatology.
17(1):53-64
[DOI] 10.1038/s41575-019-0242-7.
[PMID] 31811279.
2020
Oral therapy with colonization factor antigen I prevents development of type 1 diabetes in Non-obese Diabetic mice.
Scientific reports.
10(1)
[DOI] 10.1038/s41598-020-62881-4.
[PMID] 32273533.
2020
Seaweed natural products modify the host inflammatory response via Nrf2 signaling and alter colon microbiota composition and gene expression.
Free radical biology & medicine.
146:306-323
[DOI] 10.1016/j.freeradbiomed.2019.09.013.
[PMID] 31536771.
2020
The Cancer Microbiome: Distinguishing Direct and Indirect Effects Requires a Systemic View.
Trends in cancer.
6(3):192-204
[DOI] 10.1016/j.trecan.2020.01.004.
[PMID] 32101723.
2019
Campylobacter jejuni promotes colorectal tumorigenesis through the action of cytolethal distending toxin.
Gut.
68(2):289-300
[DOI] 10.1136/gutjnl-2018-317200.
[PMID] 30377189.
2019
Fecal Microbial Transplantation for Diseases Beyond Recurrent Clostridium Difficile Infection
Gastroenterology.
157(3):624-636
[DOI] 10.1053/j.gastro.2019.04.053.
[PMID] 31220424.
2019
Human colon mucosal biofilms from healthy or colon cancer hosts are carcinogenic.
The Journal of clinical investigation.
129(4):1699-1712
[DOI] 10.1172/JCI124196.
[PMID] 30855275.
2019
Initial microbial community of the neonatal stomach immediately after birth.
Gut microbes.
10(3):289-297
[DOI] 10.1080/19490976.2018.1520578.
[PMID] 30404568.
2019
International Cancer Microbiome Consortium consensus statement on the role of the human microbiome in carcinogenesis.
Gut.
68(9):1624-1632
[DOI] 10.1136/gutjnl-2019-318556.
[PMID] 31092590.
2019
Microbial Colonization Coordinates the Pathogenesis of a Klebsiella pneumoniae Infant Isolate.
Scientific reports.
9(1)
[DOI] 10.1038/s41598-019-39887-8.
[PMID] 30833613.
2019
Microbiota and cancer immunotherapy: in search of microbial signals.
Gut.
68(3):385-388
[DOI] 10.1136/gutjnl-2018-317220.
[PMID] 30530851.
2019
Microbiota facilitates the formation of the aminated metabolite of green tea polyphenol (-)-epigallocatechin-3-gallate which trap deleterious reactive endogenous metabolites.
Free radical biology & medicine.
131:332-344
[DOI] 10.1016/j.freeradbiomed.2018.12.023.
[PMID] 30578921.
2019
Yersiniabactin-Producing Adherent/Invasive Escherichia coli Promotes Inflammation-Associated Fibrosis in Gnotobiotic Il10-/- Mice.
Infection and immunity.
87(11)
[DOI] 10.1128/IAI.00587-19.
[PMID] 31481410.
2018
Bcl11b is essential for licensing Th2 differentiation during helminth infection and allergic asthma.
Nature communications.
9(1)
[DOI] 10.1038/s41467-018-04111-0.
[PMID] 29700302.
2018
Colorectal cancer: Hand-in-hand – colorectal cancer metastasizes with microorganisms.
Nature reviews. Gastroenterology & hepatology.
15(3):133-134
[DOI] 10.1038/nrgastro.2017.186.
[PMID] 29339812.
2018
Dual-route targeted vaccine protects efficiently against botulinum neurotoxin A complex.
Vaccine.
36(1):155-164
[DOI] 10.1016/j.vaccine.2017.11.008.
[PMID] 29180028.
2018
Intestinal microbiota enhances pancreatic carcinogenesis in preclinical models.
Carcinogenesis.
39(8):1068-1078
[DOI] 10.1093/carcin/bgy073.
[PMID] 29846515.
2018
Microbial dysbiosis associated with impaired intestinal Na+/H+ exchange accelerates and exacerbates colitis in ex germ free mice
Mucosal Immunology.
2018
Microbial dysbiosis associated with impaired intestinal Na+/H+ exchange accelerates and exacerbates colitis in ex-germ free mice.
Mucosal immunology.
11(5):1329-1341
[DOI] 10.1038/s41385-018-0035-2.
[PMID] 29875400.
2018
Microbial networking in cancer: when two toxins collide.
British journal of cancer.
118(11):1407-1409
[DOI] 10.1038/s41416-018-0101-2.
[PMID] 29773837.
2018
Microbiota-Derived Metabolic Factors Reduce Campylobacteriosis in Mice
Gastroenterology.
154(6):1751-1763.e2
[DOI] 10.1053/j.gastro.2018.01.042.
[PMID] 29408609.
2018
Precision medicine using microbiota.
Science (New York, N.Y.).
359(6371):32-34
[DOI] 10.1126/science.aar2946.
[PMID] 29302001.
2018
Publisher Correction: Bcl11b is essential for licensing Th2 differentiation during helminth infection and allergic asthma.
Nature communications.
9(1)
[DOI] 10.1038/s41467-018-05360-9.
[PMID] 30026604.
2018
Transcription factor Bcl11b is central for Th2 cell differentiation in asthma and immune response to helminths
Nature Communications.
9(1)
2017
Cancer treatment: Bacterial snack attack deactivates a drug.
Nature.
550(7676):337-339
[DOI] 10.1038/550337a.
[PMID] 29052621.
2017
Carcinogenesis and therapeutics: the microbiota perspective.
Nature microbiology.
2
[DOI] 10.1038/nmicrobiol.2017.8.
[PMID] 28225000.
2017
ClbM is a versatile, cation-promiscuous MATE transporter found in the colibactin biosynthetic gene cluster.
Biochemical and biophysical research communications.
482(4):1233-1239
[DOI] 10.1016/j.bbrc.2016.12.018.
[PMID] 27939886.
2017
Human Intestinal Microbiota and Colorectal Cancer: Moving Beyond Associative Studies.
Gastroenterology.
153(6):1475-1478
[DOI] 10.1053/j.gastro.2017.10.030.
[PMID] 29100848.
2017
Locoregional Effects of Microbiota in a Preclinical Model of Colon Carcinogenesis.
Cancer research.
77(10):2620-2632
[DOI] 10.1158/0008-5472.CAN-16-3472.
[PMID] 28416491.
2017
Microbiota as a mediator of cancer progression and therapy.
Translational research : the journal of laboratory and clinical medicine.
179:139-154
[DOI] 10.1016/j.trsl.2016.07.021.
[PMID] 27554797.
2017
Novel insights into microbiome in colitis and colorectal cancer.
Current opinion in gastroenterology.
33(6):422-427
[DOI] 10.1097/MOG.0000000000000399.
[PMID] 28877044.
2017
Optimized multiplex immunofluorescence single-cell analysis reveals tuft cell heterogeneity.
JCI insight.
2(11)
[DOI] 10.1172/jci.insight.93487.
[PMID] 28570279.
2017
The Aryl Hydrocarbon Receptor Preferentially Marks and Promotes Gut Regulatory T Cells.
Cell reports.
21(8):2277-2290
[DOI] 10.1016/j.celrep.2017.10.114.
[PMID] 29166616.
2017
Workshop Report: Modulation of Antitumor Immune Responses by Dietary and Microbial Metabolites.
Journal of the National Cancer Institute.
109(6)
[DOI] 10.1093/jnci/djx040.
[PMID] 30053241.
2016
A Rapid Screenable Assay for Compounds That Protect Against Intestinal Injury in Zebrafish Larva.
Methods in molecular biology (Clifton, N.J.).
1422:281-93
[DOI] 10.1007/978-1-4939-3603-8_25.
[PMID] 27246041.
2016
Altered intestinal microbiota-host mitochondria crosstalk in new onset Crohn’s disease.
Nature communications.
7
[DOI] 10.1038/ncomms13419.
[PMID] 27876802.
2016
Gut Microbiota and a Selectively Bred Taste Phenotype: A Novel Model of Microbiome-Behavior Relationships.
Psychosomatic medicine.
78(5):610-9
[DOI] 10.1097/PSY.0000000000000318.
[PMID] 27035357.
2016
High purity galacto-oligosaccharides enhance specific Bifidobacterium species and their metabolic activity in the mouse gut microbiome.
Beneficial microbes.
7(2):247-64
[DOI] 10.3920/BM2015.0114.
[PMID] 26839072.
2016
Intestinal Microbiota in Inflammatory Bowel Disease and Carcinogenesis: Implication for Therapeutics.
Clinical pharmacology and therapeutics.
99(6):585-7
[DOI] 10.1002/cpt.348.
[PMID] 26850686.
2016
MATE transport of the E. coli-derived genotoxin colibactin.
Nature microbiology.
1
[DOI] 10.1038/nmicrobiol.2015.9.
[PMID] 27571755.
2016
Microbiota and host immune responses: a love-hate relationship.
Immunology.
147(1):1-10
[DOI] 10.1111/imm.12538.
[PMID] 26439191.
2016
Murine Model of Intestinal Ischemia-reperfusion Injury.
Journal of visualized experiments : JoVE.
(111)
[DOI] 10.3791/53881.
[PMID] 27213580.
2016
The Innate Immune Receptor NLRX1 Functions as a Tumor Suppressor by Reducing Colon Tumorigenesis and Key Tumor-Promoting Signals.
Cell reports.
14(11):2562-75
[DOI] 10.1016/j.celrep.2016.02.064.
[PMID] 26971998.
2015
Differential Relevance of NF-κB and JNK in the Pathophysiology of Hemorrhage/Resususcitation-Induced Liver Injury after Chronic Ethanol Feeding.
PloS one.
10(9)
[DOI] 10.1371/journal.pone.0137875.
[PMID] 26367181.
2015
Inflammasome-independent role of AIM2 in suppressing colon tumorigenesis via DNA-PK and Akt.
Nature medicine.
21(8):906-13
[DOI] 10.1038/nm.3908.
[PMID] 26107252.
2015
Microbial activities and intestinal homeostasis: A delicate balance between health and disease.
Cellular and molecular gastroenterology and hepatology.
1(1):28-40
[PMID] 25729763.
2015
Partial Depletion of the Proinflammatory Monocyte Population Is Neuroprotective in the Myenteric Plexus But Not in the Basal Ganglia in a Mptp Mouse Model of Parkinson’s Disease
Brain Behavior and Immunity.
46:154-167
[DOI] 10.1016/j.bbi.2015.01.009.
[PMID] 25637482.
2015
Professor Arlette Darfeuille-Michaud: the discovery of adherent-invasive Escherichia coli.
Journal of Crohn's & colitis.
9(5):373-5
[DOI] 10.1093/ecco-jcc/jjv044.
[PMID] 25759068.
2015
SCFAs Take a Toll En Route to Metabolic Syndrome.
Cell metabolism.
22(6):954-6
[DOI] 10.1016/j.cmet.2015.11.006.
[PMID] 26636491.
2015
The Microbiome and Cancer: Is the ‘Oncobiome’ Mirage Real?
Trends in cancer.
1(1):24-35
[PMID] 26568984.
2015
The Role of Curcumin in Modulating Colonic Microbiota During Colitis and Colon Cancer Prevention.
Inflammatory bowel diseases.
21(11):2483-94
[DOI] 10.1097/MIB.0000000000000522.
[PMID] 26218141.
2014
Bugs and food: a recipe for cancer?
Cell metabolism.
20(6):937-8
[DOI] 10.1016/j.cmet.2014.11.010.
[PMID] 25470545.
2014
Chemotherapy, immunity and microbiota–a new triumvirate?
Nature medicine.
20(2):126-7
[DOI] 10.1038/nm.3473.
[PMID] 24504404.
2014
Chronic Ethanol Feeding Modulates Inflammatory Mediators, Activation Of Nuclear Factor-Κb, And Responsiveness To Endotoxin In Murine Kupffer Cells And Circulating Leukocytes.
Mediators of Inflammation.
2014
[DOI] 10.1155/2014/808695.
[PMID] 24623963.
2014
Commensal microbiota stimulate systemic neutrophil migration through induction of serum amyloid A.
Cellular microbiology.
16(7):1053-67
[DOI] 10.1111/cmi.12257.
[PMID] 24373309.
2014
Could a swimming creature inform us on intestinal diseases? Lessons from zebrafish.
Inflammatory bowel diseases.
20(5):956-66
[DOI] 10.1097/01.MIB.0000442923.85569.68.
[PMID] 24577115.
2014
Do bugs define cancer geography?
The Journal of experimental medicine.
211(3)
[DOI] 10.1084/jem.2113insight3.
[PMID] 24616475.
2014
From promotion to management: the wide impact of bacteria on cancer and its treatment.
BioEssays : news and reviews in molecular, cellular and developmental biology.
36(7):658-64
[DOI] 10.1002/bies.201400015.
[PMID] 24752750.
2014
Fusobacterium and Enterobacteriaceae: important players for CRC?
Immunology letters.
162(2 Pt A):54-61
[DOI] 10.1016/j.imlet.2014.05.014.
[PMID] 24972311.
2014
Glass Microparticulate Ingestion: An Unusual And Difficult-To-Diagnose Cause Of Chronic Abdominal Pain.
Acg Case Reports Journal.
1(3):137-9
[DOI] 10.14309/crj.2014.29.
[PMID] 26157853.
2014
GPR109a: the missing link between microbiome and good health?
Immunity.
40(1):8-10
[DOI] 10.1016/j.immuni.2013.12.009.
[PMID] 24439263.
2014
Gut commensal bacteria and regional Wnt gene expression in the proximal versus distal colon.
The American journal of pathology.
184(3):592-9
[DOI] 10.1016/j.ajpath.2013.11.029.
[PMID] 24418259.
2014
Lactobacillus acidophilus NCFM affects colonic mucosal opioid receptor expression in patients with functional abdominal pain – a randomised clinical study.
Alimentary pharmacology & therapeutics.
40(2):200-7
[DOI] 10.1111/apt.12800.
[PMID] 24853043.
2014
Microbial genomic analysis reveals the essential role of inflammation in bacteria-induced colorectal cancer.
Nature communications.
5
[DOI] 10.1038/ncomms5724.
[PMID] 25182170.
2014
Microbial imbalance and intestinal pathologies: connections and contributions.
Disease models & mechanisms.
7(10):1131-42
[DOI] 10.1242/dmm.016428.
[PMID] 25256712.
2014
Microbial-derived butyrate: an oncometabolite or tumor-suppressive metabolite?
Cell host & microbe.
16(2):143-145
[DOI] 10.1016/j.chom.2014.07.011.
[PMID] 25121740.
2014
Nucleotide-binding oligomerization domain-containing protein 2 controls host response to Campylobacter jejuni in Il10-/- mice.
The Journal of infectious diseases.
210(7):1145-54
[DOI] 10.1093/infdis/jiu148.
[PMID] 24620022.
2014
Protective mucosal immunity mediated by epithelial CD1d and IL-10.
Nature.
509(7501):497-502
[DOI] 10.1038/nature13150.
[PMID] 24717441.
2014
The microbiota protects against ischemia/reperfusion-induced intestinal injury through nucleotide-binding oligomerization domain-containing protein 2 (NOD2) signaling.
The American journal of pathology.
184(11):2965-75
[DOI] 10.1016/j.ajpath.2014.07.014.
[PMID] 25204845.
2014
Time To Enlist Life-Saving, Gutsy Allies
New Scientist.
224(2992):28-29
2013
Activation of NF-κB after chronic ethanol intake and haemorrhagic shock/resuscitation in mice.
British journal of pharmacology.
170(3):506-18
[DOI] 10.1111/bph.12224.
[PMID] 23646923.
2013
Challenges in IBD research: update on progress and prioritization of the CCFA’s research agenda.
Inflammatory bowel diseases.
19(4):677-82
[DOI] 10.1097/MIB.0b013e31828134b3.
[PMID] 23448796.
2013
Colorectal cancer: looking for answers in the microbiota.
Cancer discovery.
3(4):384-7
[DOI] 10.1158/2159-8290.CD-13-0042.
[PMID] 23580283.
2013
Diet, microbiome, and the intestinal epithelium: an essential triumvirate?
BioMed research international.
2013
[DOI] 10.1155/2013/425146.
[PMID] 23586037.
2013
Epithelial cell-specific MyD88 signaling mediates ischemia/reperfusion-induced intestinal injury independent of microbial status.
Inflammatory bowel diseases.
19(13):2857-66
[DOI] 10.1097/01.MIB.0000435445.96933.37.
[PMID] 24141713.
2013
Glafenine-induced intestinal injury in zebrafish is ameliorated by μ-opioid signaling via enhancement of Atf6-dependent cellular stress responses.
Disease models & mechanisms.
6(1):146-59
[DOI] 10.1242/dmm.009852.
[PMID] 22917923.
2013
Intestinal epithelial cell-derived μ-opioid signaling protects against ischemia reperfusion injury through PI3K signaling.
The American journal of pathology.
182(3):776-85
[DOI] 10.1016/j.ajpath.2012.11.021.
[PMID] 23291213.
2013
Microbial Influence On Colorectal Cancer
Digestive Diseases and Sciences.
58
2013
Neonatal Fc receptor expression in dendritic cells mediates protective immunity against colorectal cancer.
Immunity.
39(6):1095-107
[DOI] 10.1016/j.immuni.2013.11.003.
[PMID] 24290911.
2013
Oxymatrine prevents NF-κB nuclear translocation and ameliorates acute intestinal inflammation.
Scientific reports.
3
[DOI] 10.1038/srep01629.
[PMID] 23568217.
2013
Phosphatidylinositol 3-kinase-γ signaling promotes Campylobacter jejuni-induced colitis through neutrophil recruitment in mice.
Journal of immunology (Baltimore, Md. : 1950).
190(1):357-65
[DOI] 10.4049/jimmunol.1201825.
[PMID] 23180818.
2013
Stochastic changes over time and not founder effects drive cage effects in microbial community assembly in a mouse model.
The ISME journal.
7(11):2116-25
[DOI] 10.1038/ismej.2013.106.
[PMID] 23823492.
2013
The complex interplay between inflammation, the microbiota and colorectal cancer.
Gut microbes.
4(3):253-8
[DOI] 10.4161/gmic.24220.
[PMID] 23549517.
2013
The microbiome and cancer.
Nature reviews. Cancer.
13(11):800-12
[DOI] 10.1038/nrc3610.
[PMID] 24132111.
2013
VSL#3 probiotic modifies mucosal microbial composition but does not reduce colitis-associated colorectal cancer.
Scientific reports.
3
[DOI] 10.1038/srep02868.
[PMID] 24100376.
2012
A cell permeable peptide inhibitor of NFAT inhibits macrophage cytokine expression and ameliorates experimental colitis.
PloS one.
7(3)
[DOI] 10.1371/journal.pone.0034172.
[PMID] 22479554.
2012
Campylobacter jejuni induces colitis through activation of mammalian target of rapamycin signaling.
Gastroenterology.
142(1):86-95.e5
[DOI] 10.1053/j.gastro.2011.09.042.
[PMID] 21963787.
2012
Colorectal cancer: CRC–all about microbial products and barrier function?
Nature reviews. Gastroenterology & hepatology.
9(12):694-6
[DOI] 10.1038/nrgastro.2012.220.
[PMID] 23165234.
2012
Intestinal inflammation targets cancer-inducing activity of the microbiota.
Science (New York, N.Y.).
338(6103):120-3
[DOI] 10.1126/science.1224820.
[PMID] 22903521.
2012
Mouse background strain profoundly influences Paneth cell function and intestinal microbial composition.
PloS one.
7(2)
[DOI] 10.1371/journal.pone.0032403.
[PMID] 22384242.
2012
NLRP12 suppresses colon inflammation and tumorigenesis through the negative regulation of noncanonical NF-κB signaling.
Immunity.
36(5):742-54
[DOI] 10.1016/j.immuni.2012.03.012.
[PMID] 22503542.
2012
Probiotic bacteria produce conjugated linoleic acid locally in the gut that targets macrophage PPAR γ to suppress colitis.
PloS one.
7(2)
[DOI] 10.1371/journal.pone.0031238.
[PMID] 22363592.
2012
Retinal not systemic oxidative and inflammatory stress correlated with VEGF expression in rodent models of insulin resistance and diabetes.
Investigative ophthalmology & visual science.
53(13):8424-32
[DOI] 10.1167/iovs.12-10207.
[PMID] 23197686.
2012
The microbiota is essential for the generation of black tea theaflavins-derived metabolites.
PloS one.
7(12)
[DOI] 10.1371/journal.pone.0051001.
[PMID] 23227227.
2012
The short isoform of the CEACAM1 receptor in intestinal T cells regulates mucosal immunity and homeostasis via Tfh cell induction.
Immunity.
37(5):930-46
[DOI] 10.1016/j.immuni.2012.07.016.
[PMID] 23123061.
2012
Think small: zebrafish as a model system of human pathology.
Journal of biomedicine & biotechnology.
2012
[DOI] 10.1155/2012/817341.
[PMID] 22701308.
2012
Time dependency and topography of hepatic nuclear factor κB activation after hemorrhagic shock and resuscitation in mice.
Shock (Augusta, Ga.).
38(5):486-92
[DOI] 10.1097/SHK.0b013e3182699072.
[PMID] 22814290.
2011
Gut microbial diversity is reduced by the probiotic VSL#3 and correlates with decreased TNBS-induced colitis.
Inflammatory bowel diseases.
17(1):289-97
[DOI] 10.1002/ibd.21366.
[PMID] 20564535.
2011
Microbial colonization induces dynamic temporal and spatial patterns of NF-κB activation in the zebrafish digestive tract.
Gastroenterology.
141(1):197-207
[DOI] 10.1053/j.gastro.2011.03.042.
[PMID] 21439961.
2011
Mu opioid signaling protects against acute murine intestinal injury in a manner involving Stat3 signaling.
The American journal of pathology.
179(2):673-83
[DOI] 10.1016/j.ajpath.2011.04.032.
[PMID] 21801866.
2011
PI3K-dependent GSK3ß(Ser9)-phosphorylation is implicated in the intestinal epithelial cell wound-healing response.
PloS one.
6(10)
[DOI] 10.1371/journal.pone.0026340.
[PMID] 22039465.
2011
Pretreatment with the probiotic VSL#3 delays transition from inflammation to dysplasia in a rat model of colitis-associated cancer.
American journal of physiology. Gastrointestinal and liver physiology.
301(6):G1004-13
[DOI] 10.1152/ajpgi.00167.2011.
[PMID] 21903764.
2011
Structural identification of mouse fecal metabolites of theaflavin 3,3′-digallate using liquid chromatography tandem mass spectrometry.
Journal of chromatography. A.
1218(41):7297-306
[DOI] 10.1016/j.chroma.2011.08.056.
[PMID] 21906744.
2011
The hydroxylase inhibitor dimethyloxallyl glycine attenuates endotoxic shock via alternative activation of macrophages and IL-10 production by B1 cells.
Shock (Augusta, Ga.).
36(3):295-302
[DOI] 10.1097/SHK.0b013e318225ad7e.
[PMID] 21844787.
2011
The struggle within: microbial influences on colorectal cancer.
Inflammatory bowel diseases.
17(1):396-409
[DOI] 10.1002/ibd.21354.
[PMID] 20848537.
2010
Alleviating cancer drug toxicity by inhibiting a bacterial enzyme.
Science (New York, N.Y.).
330(6005):831-5
[DOI] 10.1126/science.1191175.
[PMID] 21051639.
2010
Downregulation of aging-related Klotho gene in experimental colitis: the role of TNF and IFNGamma
Gastroenterology.
138(4):1384-1394
2010
High-fat diet: bacteria interactions promote intestinal inflammation which precedes and correlates with obesity and insulin resistance in mouse.
PloS one.
5(8)
[DOI] 10.1371/journal.pone.0012191.
[PMID] 20808947.
2010
MyD88 signaling in the intestine: Dr Jekyll and Mr Hyde?
Gastroenterology.
139(2):383-5
[DOI] 10.1053/j.gastro.2010.06.027.
[PMID] 20600062.
2010
Probiotics and ileitis: could augmentation of TNF/NFκB activity be the answer?
Gut microbes.
1(3):196-9
[DOI] 10.4161/gmic.1.3.12485.
[PMID] 21327025.
2010
The NLRP3 inflammasome functions as a negative regulator of tumorigenesis during colitis-associated cancer.
The Journal of experimental medicine.
207(5):1045-56
[DOI] 10.1084/jem.20100050.
[PMID] 20385749.
2010
Tumor necrosis factor and interferon-gamma down-regulate Klotho in mice with colitis.
Gastroenterology.
138(4):1384-94, 1394.e1
[DOI] 10.1053/j.gastro.2009.12.002.
[PMID] 20004202.
2009
Gnotobiotic IL-10; NF-kappaB mice develop rapid and severe colitis following Campylobacter jejuni infection.
PloS one.
4(10)
[DOI] 10.1371/journal.pone.0007413.
[PMID] 19841748.
2009
Intestinal epithelial-derived TAK1 signaling is essential for cytoprotection against chemical-induced colitis.
PloS one.
4(2)
[DOI] 10.1371/journal.pone.0004561.
[PMID] 19234607.
2009
Microbes And Colorectal Cancer: Is There A Relationship?
Current Oncology (Toronto, Ont.).
16(4):22-4
[DOI] 10.3747/co.v16i4.472.
[PMID] 19672421.
2009
Modulation of the intestinal microbiota alters colitis-associated colorectal cancer susceptibility.
PloS one.
4(6)
[DOI] 10.1371/journal.pone.0006026.
[PMID] 19551144.
2009
Tomato lycopene extract prevents lipopolysaccharide-induced NF-kappaB signaling but worsens dextran sulfate sodium-induced colitis in NF-kappaBEGFP mice.
PloS one.
4(2)
[DOI] 10.1371/journal.pone.0004562.
[PMID] 19234608.
2009
Wound Healing Responses At The Gastrointestinal Epithelium: A Close Look At Novel Regulatory Factors And Investigative Approaches.
Zeitschrift Fur Gastroenterologie.
47(12):1221-9
[DOI] 10.1055/s-0028-1109766.
[PMID] 19960401.
2008
Enterocyte-derived TAK1 signaling prevents epithelium apoptosis and the development of ileitis and colitis.
Journal of immunology (Baltimore, Md. : 1950).
181(2):1143-52
[PMID] 18606667.
2008
Impaired Bcl3 up-regulation leads to enhanced lipopolysaccharide-induced interleukin (IL)-23P19 gene expression in IL-10(-/-) mice.
The Journal of biological chemistry.
283(21):14182-9
[DOI] 10.1074/jbc.M709029200.
[PMID] 18375954.
2008
Interleukin-8 expression is regulated by histone deacetylases through the nuclear factor-kappaB pathway in breast cancer.
Molecular pharmacology.
74(5):1359-66
[DOI] 10.1124/mol.108.047332.
[PMID] 18669446.
2008
Limited Effects Of Dietary Curcumin On Th-1 Driven Colitis In Il-10 Deficient Mice Suggest An Il-10-Dependent Mechanism Of Protection.
American Journal of Physiology-Gastrointestinal and Liver Physiology.
295(5):G1079-91
[DOI] 10.1152/ajpgi.90365.2008.
[PMID] 18818316.
2008
Nf-kappa B signaling cascade and IBD: turn it down?
Inflammatory bowel diseases.
14 Suppl 2:S108-9
[DOI] 10.1002/ibd.20717.
[PMID] 18816651.
2008
NF-kappaB and the intestine: friend or foe?
Inflammatory bowel diseases.
14(1):114-24
[PMID] 17763472.
2008
Regulation and functional impact of lipopolysaccharide induced Nod2 gene expression in the murine epididymal epithelial cell line PC1.
Immunology.
124(2):256-64
[DOI] 10.1111/j.1365-2567.2007.02763.x.
[PMID] 18284470.
2008
Toll-like receptor 9-dependent macrophage activation by Entamoeba histolytica DNA.
Infection and immunity.
76(1):289-97
[PMID] 17984204.
2007
Amelioration of chronic murine colitis by peptide-mediated transduction of the IkappaB kinase inhibitor NEMO binding domain peptide.
Journal of immunology (Baltimore, Md. : 1950).
179(11):7852-9
[PMID] 18025231.
2007
Dual-association of gnotobiotic IL-10-/- mice with 2 nonpathogenic commensal bacteria induces aggressive pancolitis.
Inflammatory bowel diseases.
13(12):1457-66
[PMID] 17763473.
2007
Gnotobiotic IL-10-/-;NF-kappa B(EGFP) mice reveal the critical role of TLR/NF-kappa B signaling in commensal bacteria-induced colitis.
Journal of immunology (Baltimore, Md. : 1950).
178(10):6522-32
[PMID] 17475882.
2007
The flavonoid luteolin worsens chemical-induced colitis in NF-kappaB(EGFP) transgenic mice through blockade of NF-kappaB-dependent protective molecules.
PloS one.
2(7)
[PMID] 17611628.
2006
Critical role for H3 phosphorylation and p38-MAPK pathway in intestinal wound-healing response
American Journal of Physiology-Cell Physiology.
207(3):809-815
2006
Wound-induced p38MAPK-dependent histone H3 phosphorylation correlates with increased COX-2 expression in enterocytes.
Journal of cellular physiology.
207(3):809-15
[PMID] 16508963.
2005
Activation of NF-kappaB following detachment delays apoptosis in intestinal epithelial cells.
Oncogene.
24(43):6482-91
[PMID] 16007176.
2005
Adenosine is a negative regulator of NF-kappaB and MAPK signaling in human intestinal epithelial cells.
Cellular immunology.
237(2):86-95
[PMID] 16413516.
2005
Inhibition of macrophage nuclear factor-kappaB leads to a dominant anti-inflammatory phenotype that attenuates glomerular inflammation in vivo.
The American journal of pathology.
167(1):27-37
[PMID] 15972949.
2005
Regulation Of Tnf-Related Apoptosis-Inducing Ligand-Mediated Death-Signal Pathway In Human Beta Cells By Fas-Associated Death Domain And Nuclear Factor Kappab.
Human Immunology.
66(7):799-809
[PMID] 16112027.
2005
Salvia Miltiorrhiza Water-Soluble Extract, But Not Its Constituent Salvianolic Acid B, Abrogates Lps-Induced Nf-Kappab Signalling In Intestinal Epithelial Cells.
Clinical and Experimental Immunology.
141(2):288-97
[DOI] 10.1111/j.1365-2249.2005.02844.x.
[PMID] 15996193.
2005
Serum amyloid A activates NF-kappaB and proinflammatory gene expression in human and murine intestinal epithelial cells.
European journal of immunology.
35(3):718-26
[PMID] 15724247.
2005
STAT3 regulates NF-kappaB recruitment to the IL-12p40 promoter in dendritic cells.
Blood.
105(2):689-96
[PMID] 15251981.
2005
The flavonoid luteolin prevents lipopolysaccharide-induced NF-kappaB signalling and gene expression by blocking IkappaB kinase activity in intestinal epithelial cells and bone-marrow derived dendritic cells.
Immunology.
115(3):375-87
[PMID] 15946255.
2005
Tumor necrosis factor (TNF) alpha increases collagen accumulation and proliferation in intestinal myofibroblasts via TNF receptor 2.
The Journal of biological chemistry.
280(43):36099-109
[PMID] 16141211.
2005
Ubiquitin protein modification and signal transduction: implications for inflammatory bowel diseases.
Inflammatory bowel diseases.
11(12):1097-107
[PMID] 16306773.
2004
Differential Effect Of Immune Cells On Non-Pathogenic Gram-Negative Bacteria-Induced Nuclear Factor-Kappab Activation And Pro-Inflammatory Gene Expression In Intestinal Epithelial Cells.
Immunology.
112(2):310-20
[DOI] 10.1111/j.1365-2567.2004.01874.x.
[PMID] 15147574.
2004
Differential effects of deoxycholic acid and taurodeoxycholic acid on NF-kappa B signal transduction and IL-8 gene expression in colonic epithelial cells.
American journal of physiology. Gastrointestinal and liver physiology.
286(6):G1000-8
[PMID] 14726307.
2004
Down-regulation of MEK/ERK signaling by E-cadherin-dependent PI3K/Akt pathway in differentiating intestinal epithelial cells.
Journal of cellular physiology.
199(1):32-9
[PMID] 14978732.
2004
In vivo pattern of lipopolysaccharide and anti-CD3-induced NF-kappa B activation using a novel gene-targeted enhanced GFP reporter gene mouse.
Journal of immunology (Baltimore, Md. : 1950).
173(3):1561-70
[PMID] 15265883.
2004
Interaction between resident luminal bacteria and the host: can a healthy relationship turn sour?
Journal of pediatric gastroenterology and nutrition.
38(2):123-36
[PMID] 14734871.
2004
Loss Of E-Cadherin Leads To Upregulation Of Nfkappab Activity In Malignant Melanoma.
Oncogene.
23(52):8509-19
[PMID] 15378016.
2004
NF-kappaB inducing kinase activates NF-kappaB transcriptional activity independently of IkappaB kinase gamma through a p38 MAPK-dependent RelA phosphorylation pathway.
Cellular signalling.
16(9):1023-32
[PMID] 15212763.
2004
NF-kappaB-inducing kinase restores defective IkappaB kinase activity and NF-kappaB signaling in intestinal epithelial cells.
Cellular signalling.
16(6):741-50
[PMID] 15093615.
2004
Role of NF-kappaB in inflammatory disorders: just when you thought you knew everything!
Journal of pediatric gastroenterology and nutrition.
38(1):109-10
[PMID] 14733184.
2003
Butyrate modulates intestinal epithelial cell-mediated neutrophil migration.
Clinical and experimental immunology.
131(1):53-60
[PMID] 12519386.
2003
Intestinal epithelial cells and innate immunity in the intestine: is CARD15/Nod2 another player?
Gastroenterology.
124(4):1145-9
[PMID] 12671908.
2003
Toll-like receptor 4 mediates inflammatory signaling by bacterial lipopolysaccharide in human hepatic stellate cells.
Hepatology (Baltimore, Md.).
37(5):1043-55
[PMID] 12717385.
2003
Transforming growth factor-beta 1 inhibits non-pathogenic Gram negative bacteria-induced NF-kappa B recruitment to the interleukin-6 gene promoter in intestinal epithelial cells through modulation of histone acetylation.
The Journal of biological chemistry.
278(26):23851-60
[PMID] 12672795.
2002
Constitutive nuclear factor-kappa B activity is required for central neuron survival.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
22(19):8466-75
[PMID] 12351721.
2002
Differential requirement for NF-kappaB-inducing kinase in the induction of NF-kappaB by IL-1beta, TNF-alpha, and Fas.
American journal of physiology. Cell physiology.
283(1):C347-57
[PMID] 12055104.
2002
IKK beta and phosphatidylinositol 3-kinase/Akt participate in non-pathogenic Gram-negative enteric bacteria-induced RelA phosphorylation and NF-kappa B activation in both primary and intestinal epithelial cell lines.
The Journal of biological chemistry.
277(41):38168-78
[PMID] 12140289.
2001
Cryptosporidium parvum activates nuclear factor kappaB in biliary epithelia preventing epithelial cell apoptosis.
Gastroenterology.
120(7):1774-83
[PMID] 11375958.
2001
Inhibition of cytokine-induced NF-kappaB activation by adenovirus-mediated expression of a NF-kappaB super-repressor prevents beta-cell apoptosis.
Diabetes.
50(10):2219-24
[PMID] 11574401.
2001
Regulatory role of phosphatidylinositol 3-kinase on TNF-alpha-induced cyclooxygenase 2 expression in colonic epithelial cells.
Gastroenterology.
120(5):1117-27
[PMID] 11266376.
2000
Cellular differentiation causes a selective down-regulation of interleukin (IL)-1beta-mediated NF-kappaB activation and IL-8 gene expression in intestinal epithelial cells.
The Journal of biological chemistry.
275(16):12207-13
[PMID] 10766857.
2000
NF-kappaB signaling proteins as therapeutic targets for inflammatory bowel diseases.
Inflammatory bowel diseases.
6(3):206-13
[PMID] 10961593.
2000
The I kappa B/NF-kappa B system: a key determinant of mucosalinflammation and protection.
American journal of physiology. Cell physiology.
278(3):C451-62
[PMID] 10712233.
1999
Curcumin Blocks Cytokine-Mediated Nf-Kappa B Activation And Proinflammatory Gene Expression By Inhibiting Inhibitory Factor I-Kappa B Kinase Activity.
Journal of immunology (Baltimore, Md. : 1950).
163(6):3474-83
[PMID] 10477620.
1999
Molecular and cellular biology of the small intestine.
Current opinion in gastroenterology.
15(2):103-7
[PMID] 17023928.
1999
Suppression Of Nf-Kappab-Dependent Proinflammatory Gene Expression In Human Rpe Cells By A Proteasome Inhibitor.
Investigative Ophthalmology & Visual Science.
40(2):477-86
[PMID] 9950608.
1999
Tnf Receptor-Associated Factor-2 Is Involved In Both Il-1 Beta And Tnf-Alpha Signaling Cascades Leading To Nf-Kappa B Activation And Il-8 Expression In Human Intestinal Epithelial Cells.
Journal of immunology (Baltimore, Md. : 1950).
162(8):4447-54
[PMID] 10201981.
1998
Cytokines induce NF-kappaB in activated but not in quiescent rat hepatic stellate cells.
The American journal of physiology.
275(2):G269-78
[DOI] 10.1152/ajpgi.1998.275.2.G269.
[PMID] 9688654.
1998
Differential Expression Of Interleukin 1 Receptor Antagonist Isoforms In Human Intestinal Epithelial Cells.
Gastroenterology.
115(6):1426-38
[PMID] 9834270.
1998
Inhibition Of Nfkappab In Activated Rat Hepatic Stellate Cells By Proteasome Inhibitors And An Ikappab Super-Repressor.
Hepatology.
27(5):1285-95
[PMID] 9581682.
1998
Inhibition of proinflammatory molecule production by adenovirus-mediated expression of a nuclear factor kappaB super-repressor in human intestinal epithelial cells.
Journal of immunology (Baltimore, Md. : 1950).
160(1):410-8
[PMID] 9551998.
1998
Mediation by NF-kappa B of cytokine induced expression of intercellular adhesion molecule 1 (ICAM-1) in an intestinal epithelial cell line, a process blocked by proteasome inhibitors.
Gut.
42(6):779-87
[PMID] 9691914.
1998
Specific NF-kappaB blockade selectively inhibits tumour necrosis factor-alpha-induced COX-2 but not constitutive COX-1 gene expression in HT-29 cells.
Immunology.
95(4):537-43
[PMID] 9893042.
1997
Differential Effects Of Cell Density On 5-Lipoxygenase (5-Lo), Five-Lipoxygenase-Activating Protein (Flap) And Interleukin-1 Beta (Il-1 Beta) Expression In Human Neutrophils.
Inflammation.
21(2):235-50
[PMID] 9187965.
1997
Evidence For Altered Regulation Of I Kappa B Alpha Degradation In Human Colonic Epithelial Cells.
Journal of immunology (Baltimore, Md. : 1950).
158(1):226-34
[PMID] 8977194.
1991
Differential Synthesis Of 5-Lipoxygenase In Peripheral Blood And Synovial Fluid Neutrophils In Rheumatoid Arthritis.
Journal of immunology (Baltimore, Md. : 1950).
146(8):2701-7
[PMID] 2016523.
Grants
May 2025
ACTIVE
ReSubmission R01 Role of bacterial-derived small molecules in immunotherapy
Role: Principal Investigator
Funding: NATL INST OF HLTH NCI
Jan 2025
ACTIVE
Interaction between dietary taurine and microbiota sulfur metabolism in the development of colorectal cancer
Role: Principal Investigator
Funding: NATL INST OF HLTH NCI
Apr 2024
ACTIVE
UF Health Cancer Center Bridge Seed Grant (Continued)
Role: Project Manager
Funding: UF HEALTH SHANDS HOSPITAL
Oct 2023
ACTIVE
The Gastrointestinal Microbiota and Breast Cancer
Role: Project Manager
Funding: MEDICAL COLLEGE OF VIRGINIA FOUNDATION
via BRISTOL-MYERS SQUIBB FOUNDATION
Jun 2023
ACTIVE
UF Health Cancer Center Support Grant
Role: Other
Funding: NATL INST OF HLTH NCI
May 2023
ACTIVE
Microbiota, Metabolites, and Colon Neoplasia
Role: Principal Investigator
Funding: UNIV OF CONNECTICUT
via NATL INST OF HLTH NCI
Mar 2023
ACTIVE
Chemical Approaches Toward the Identification, Functional Analysis and Biosynthesis of Small Molecule Cyclomodulins
Role: Principal Investigator
Funding: YALE UNIV
via NATL INST OF HLTH NCI
Feb 2023
ACTIVE
Deciphering microbial contribution to androgen bioavailability in castration resistant prostate cancer patients
Role: Principal Investigator
Funding: NATL INST OF HLTH NCI
Jul 2022
– May 2025
Microbiota-mediated enhancement of the anti-tumor effect of natural killer cells
Role: Principal Investigator
Funding: NATL INST OF HLTH NCI
May 2022
– Feb 2025
Bacteriophage-mediated microbiota modification to prevent colorectal cancer development
Role: Principal Investigator
Funding: NATL INST OF HLTH NCI
Dec 2021
ACTIVE
Bacteriophages as Modulators of Bacterial Colonization
Role: Other
Funding: NATL INST OF HLTH NIAID
Aug 2021
ACTIVE
Role of RORgt+ (note: g: is gamma symbol) lymphocytes in Gut Tissue Homeostasis
Role: Co-Investigator
Funding: NATL INST OF HLTH NIAID
Jul 2021
– Jun 2024
Exploiting microbiota metabolism for colorectal cancer prevention
Role: Principal Investigator
Funding: YALE UNIV
via US ARMY MED RES ACQUISITION
Jun 2021
– Nov 2023
Modulation of microbiome function by host-derived noncoding small RNA
Role: Principal Investigator
Funding: NATL INST OF HLTH NIAID
Mar 2019
– Nov 2023
Role of the microbiota in DNA methylation and CRC development
Role: Principal Investigator
Funding: CORIELL INSTITUTE FOR MEDICAL RESEARCH
via NATL INST OF HLTH NCI
Jan 2019
– Nov 2024
Human milk metabolomics and microbe-host interactions associated with pediatric obesity
Role: Other
Funding: NATL INST OF HLTH NIDDK
Jul 2018
– Apr 2025
Role of Bacteria in Colitis-Associated Colon Cancer
Role: Principal Investigator
Funding: NATL INST OF HLTH NIDDK
Jan 2018
– Dec 2023
The role of the microbiome on pancreatic carcinogenesis in a murine model
Role: Other
Funding: AMERICAN CANCER SOCIETY
Dec 2017
– Feb 2019
Role of the microbiota in DNA methylation and CRC development
Role: Principal Investigator
Funding: TEMPLE UNIVERSITY
via NATL INST OF HLTH NCI
Dec 2017
– Feb 2023
Chemical approaches toward the identification, functional analysis, and biosynthesis of small molecule cyclomodulin
Role: Principal Investigator
Funding: YALE UNIV
via NATL INST OF HLTH NCI
Oct 2016
– Sep 2018
Role of Gram negative bacterial lipopolysaccharide in CXCR4-mediated pancreatic carcinogenesis
Role: Faculty
Funding: ASSOC OF VA SURGEONS FOU
Aug 2016
– Dec 2021
ACE2, Brain, Gut Dysbiosis in Pulmonary Hypertension
Role: Co-Investigator
Funding: NATL INST OF HLTH NHLBI
Jul 2016
– Jun 2019
Impact of host signaling on microbial activities in the development of colitis-associated colorectal cancer
Role: Other
Funding: CROHNS & COLITIS FOUNDATION
Apr 2016
– Sep 2021
Brain-Gut Microbiome-Immune Axis in Hypertension
Role: Project Manager
Funding: NATL INST OF HLTH NHLBI
Dec 2015
– Nov 2019
Mechanism by which H2S-producing bacteria influence development of colorectal cancer
Role: Principal Investigator
Funding: NATL INST OF HLTH NCI
Jul 2015
– Jun 2024
Florida Academic Cancer Center Alliance Seed Grants
Role: Project Manager
Funding: UF HEALTH SHANDS HOSPITAL
Jun 2015
– Nov 2017
Microbial Factors Implicated in the Development of Colorectal Cancer
Role: Principal Investigator
Funding: UF DSR OPPORTUNITY FUND
Feb 2015
– Oct 2023
UF Health Cancer Center Pilot Project Grants funded through the Florida Consortium of National Cancer Institute Centers Program
Role: Project Manager
Funding: UF HEALTH SHANDS HOSPITAL
Jan 2015
– Dec 2021
Impact of microbiota-mediated biotransformation of black tea polyphenols on GI health
Role: Principal Investigator
Funding: NATL CTR FOR COMPLEM AND INTEGRATIVE HLT
May 2014
– May 2019
Multiple Sponsors
Role: Principal Investigator
Funding: MULTIPLE SPONSORS
Jul 2013
– Jun 2021
Florida Center for Brain Tumor Research – Statewide Brain Tumor Registry Program at the McKnight Brain Institute
Role: Project Manager
Funding: FL DEPT OF HLTH
Jul 2013
– Mar 2018
Role of Bacteria in Colitis-Associated Colon Cancer
Role: Principal Investigator
Funding: NATL INST OF HLTH NIDDK
Jul 2013
– Jun 2016
Regulation of Immunosuppressive Molecules in IBD
Role: Principal Investigator
Funding: NATL INST OF HLTH NIDDK
Contact Details
Phones:
- Business:
- (352) 294-5148
Emails:
- Business:
- cjobin@ufl.edu
Addresses:
- Business Mailing:
-
CGRC-461
CGRC-461
2033 MOWRY RD
GAINESVILLE FL 326100001 - Business Street:
-
2033 MOWRY RD
GAINESVILLE FL 32611