Christian Jobin, Ph.D.
Professor Of Medicine; Principal Investigator
Accomplishments
Associate Editor
2017-2020
·
Microbiome
Chair study section for Program Project Grant exploring the metabolic, epigenetic and microbiome drivers of inflammation driven malignancy
2017
·
Terry Fox Research Institute
Permanent Member
2015-2020
·
NIH GMPB
UF Senior Faculty Excellence in Research Award
2015
·
University of Florida
Study Section Memberships – Advisory Board
2014-2016
·
CIHR Institute Advisory Board of Infection and Immunity
Study Section Memberships – Advisory Board
2014-2015
·
AICR
Study Section Memberships -Advisory Board
2014-2015
·
American Society for Cancer
Study Section Memberships – Advisory Board
2013-2020
·
NIH NCI Chair ZRG1 DKUS-D: Role of the Microflora in the Etiology of Gastrointestinal Cancer
Study Section Memberships – Advisory Board
2011-2020
·
Ad Hoc NIH Gastrointestinal Mucosal Pathobiology (GMBP)
Study Section Memberships – Advisory Board
2010-2013
·
Canadian Institutes of Health Research, Vanier Canada Graduate Scholarships
Admission Committee
2009-2012
·
UNC Biological and Biomedical Sciences Program
IBD: Associate Editor
2008-2016
·
Cell Biology/Biochemistry/Molecular Biology
Study Section Memberships – Advisory Board
2008-2011
·
CCFA Study section (Fellowship and Career Awards)
Study Section
2007-2020
·
NIH Tumor Microenvironment (TME)
IBD: Section Editor
2007-2008
·
Cell Biology/Biochemistry/Molecular Biology
Editorial Board Member
2005-2010
·
Gastroenterology
Fireman Young Scientist Basic Research Award
2005
·
American Gastroenterological Association
Junior Faculty Development Award
2005
·
UNC
University Research Council Award
2004
·
Mucosal Immunology Society
Study Section Memberships – Advisory Board
2003-2007
·
Canadian Institutes of Health Research, Experimental Medicine
Study Section Memberships – Advisory Board
2002-2020
·
Ad Hoc NIH Special Emphasis Panel NIDDK
Editorial Board Member
2001-2009
·
American Journal of Physiology
Anne Ferguson Award
1999
·
Mucosal Immunology Society
Young investigator travel award
1999
·
Mucosal Immunology
Career Development Award
1998-1999
·
CCFA
CCFA Young IBD Investigator Award
1998
·
“Regulation and modulation of the IkB/NF-kB transcriptional system in intestinal epithelial cells”
University Research Council Award
1998
·
University Research Council Award
CCFA young investigator travel award
1996
·
“Immune/non-immune cell interaction in intestinal inflammation” meeting in Florida
CCFA young investigator travel award
1995
·
“Interactions between genetics and microbiology in inflammatory bowel disease” meeting in South Carolina
Ph.D fellowships
1991-1993
·
Laval University
Ph.D fellowship
1990-1991
·
Hôpital Saint-François d’Assise
Publications
2021
Avenanthramide Metabotype from Whole-Grain Oat Intake is Influenced by Faecalibacterium prausnitzii in Healthy Adults.
The Journal of nutrition.
[DOI] 10.1093/jn/nxab006.
[PMID] 33694368.
2021
Bacteria break barrier to promote metastasis.
Cancer cell.
[DOI] 10.1016/j.ccell.2021.03.009.
[PMID] 33891891.
2021
Bacterial Swarmers Enriched During Intestinal Stress Ameliorate Damage.
Gastroenterology.
[DOI] 10.1053/j.gastro.2021.03.017.
[PMID] 33741315.
2021
Black Tea Theaflavin Detoxifies Metabolic Toxins in the Intestinal Tract of Mice.
Molecular nutrition & food research.
65(4)
[DOI] 10.1002/mnfr.202000887.
[PMID] 33381889.
2021
Gut Microbiota Dysbiosis Associated with Persistent Fatigue in Hematopoietic Cell Transplantation Survivors.
Transplantation and cellular therapy.
[DOI] 10.1016/j.jtct.2021.02.017.
[PMID] 33775619.
2021
Implications of the microbiome in the development and treatment of pancreatic cancer: Thinking outside of the box by looking inside the gut.
Neoplasia (New York, N.Y.).
23(2):246-256
[DOI] 10.1016/j.neo.2020.12.008.
[PMID] 33418277.
2021
Microbiome-Derived Liquid Biopsy: New Hope for Cancer Screening?
Clinical chemistry.
67(3):463-465
[DOI] 10.1093/clinchem/hvaa240.
[PMID] 33277898.
2021
Microbiota phylogenic analysis revealed decreased abundance of Faecalibacterium prausnitzii, an anti-inflammatory commensal bacterium, in patients with chronic graft-versus-host disease.
Hematology/oncology and stem cell therapy.
[DOI] 10.1016/j.hemonc.2021.03.004.
[PMID] 33785388.
2021
NTPDase8 protects mice from intestinal inflammation by limiting P2Y6 receptor activation: identification of a new pathway of inflammation for the potential treatment of IBD.
Gut.
[DOI] 10.1136/gutjnl-2020-320937.
[PMID] 33452178.
2020
A mutational signature that can be made by a bacterium arises in human colon cancer.
Nature.
580(7802):194-195
[DOI] 10.1038/d41586-020-00818-7.
[PMID] 32203380.
2020
Amending microbiota by targeting intestinal inflammation with TNF blockade attenuates development of colorectal cancer.
Nature cancer.
1(7):723-734
[DOI] 10.1038/s43018-020-0078-7.
[PMID] 33768208.
2020
Baseline Gut Microbiota Composition Is Associated with Major Infections Early after Hematopoietic Cell Transplantation.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation.
26(11):2001-2010
[DOI] 10.1016/j.bbmt.2020.07.023.
[PMID] 32717434.
2020
Characterization of the bacterial microbiome among free-ranging bottlenose dolphins (Tursiops truncatus).
Heliyon.
6(6)
[DOI] 10.1016/j.heliyon.2020.e03944.
[PMID] 32577542.
2020
Dietary iron variably modulates assembly of the intestinal microbiota in colitis-resistant and colitis-susceptible mice.
Gut microbes.
11(1):32-50
[DOI] 10.1080/19490976.2019.1599794.
[PMID] 31179826.
2020
Far reach of Fusobacterium nucleatum in cancer metastasis.
Gut.
[DOI] 10.1136/gutjnl-2020-323496.
[PMID] 33323393.
2020
Gut microbiota maturation during early human life induces enterocyte proliferation via microbial metabolites.
BMC microbiology.
20(1)
[DOI] 10.1186/s12866-020-01892-7.
[PMID] 32652929.
2020
Human Colon Mucosal Biofilms and Murine Host Communicate via Altered mRNA and microRNA Expression during Cancer.
mSystems.
5(1)
[DOI] 10.1128/mSystems.00451-19.
[PMID] 31937674.
2020
Microbiota in pancreatic health and disease: the next frontier in microbiome research.
Nature reviews. Gastroenterology & hepatology.
17(1):53-64
[DOI] 10.1038/s41575-019-0242-7.
[PMID] 31811279.
2020
Oral therapy with colonization factor antigen I prevents development of type 1 diabetes in Non-obese Diabetic mice.
Scientific reports.
10(1)
[DOI] 10.1038/s41598-020-62881-4.
[PMID] 32273533.
2020
Seaweed natural products modify the host inflammatory response via Nrf2 signaling and alter colon microbiota composition and gene expression.
Free radical biology & medicine.
146:306-323
[DOI] 10.1016/j.freeradbiomed.2019.09.013.
[PMID] 31536771.
2020
The Cancer Microbiome: Distinguishing Direct and Indirect Effects Requires a Systemic View.
Trends in cancer.
6(3):192-204
[DOI] 10.1016/j.trecan.2020.01.004.
[PMID] 32101723.
2019
Campylobacter jejuni promotes colorectal tumorigenesis through the action of cytolethal distending toxin.
Gut.
68(2):289-300
[DOI] 10.1136/gutjnl-2018-317200.
[PMID] 30377189.
2019
Fecal Microbial Transplantation for Diseases Beyond Recurrent Clostridium Difficile Infection.
Gastroenterology.
157(3):624-636
[DOI] 10.1053/j.gastro.2019.04.053.
[PMID] 31220424.
2019
Human colon mucosal biofilms from healthy or colon cancer hosts are carcinogenic.
The Journal of clinical investigation.
129(4):1699-1712
[DOI] 10.1172/JCI124196.
[PMID] 30855275.
2019
Initial microbial community of the neonatal stomach immediately after birth.
Gut microbes.
10(3):289-297
[DOI] 10.1080/19490976.2018.1520578.
[PMID] 30404568.
2019
International Cancer Microbiome Consortium consensus statement on the role of the human microbiome in carcinogenesis.
Gut.
68(9):1624-1632
[DOI] 10.1136/gutjnl-2019-318556.
[PMID] 31092590.
2019
Microbial Colonization Coordinates the Pathogenesis of a Klebsiella pneumoniae Infant Isolate.
Scientific reports.
9(1)
[DOI] 10.1038/s41598-019-39887-8.
[PMID] 30833613.
2019
Microbiota and cancer immunotherapy: in search of microbial signals.
Gut.
68(3):385-388
[DOI] 10.1136/gutjnl-2018-317220.
[PMID] 30530851.
2019
Microbiota facilitates the formation of the aminated metabolite of green tea polyphenol (-)-epigallocatechin-3-gallate which trap deleterious reactive endogenous metabolites.
Free radical biology & medicine.
131:332-344
[DOI] 10.1016/j.freeradbiomed.2018.12.023.
[PMID] 30578921.
2019
Yersiniabactin-Producing Adherent/Invasive Escherichia coli Promotes Inflammation-Associated Fibrosis in Gnotobiotic Il10-/- Mice.
Infection and immunity.
87(11)
[DOI] 10.1128/IAI.00587-19.
[PMID] 31481410.
2018
Bcl11b is essential for licensing Th2 differentiation during helminth infection and allergic asthma.
Nature communications.
9(1)
[DOI] 10.1038/s41467-018-04111-0.
[PMID] 29700302.
2018
Colorectal cancer: Hand-in-hand – colorectal cancer metastasizes with microorganisms.
Nature reviews. Gastroenterology & hepatology.
15(3):133-134
[DOI] 10.1038/nrgastro.2017.186.
[PMID] 29339812.
2018
Dual-route targeted vaccine protects efficiently against botulinum neurotoxin A complex.
Vaccine.
36(1):155-164
[DOI] 10.1016/j.vaccine.2017.11.008.
[PMID] 29180028.
2018
Intestinal microbiota enhances pancreatic carcinogenesis in preclinical models.
Carcinogenesis.
39(8):1068-1078
[DOI] 10.1093/carcin/bgy073.
[PMID] 29846515.
2018
Microbial dysbiosis associated with impaired intestinal Na+/H+ exchange accelerates and exacerbates colitis in ex germ free mice
Mucosal Immunology.
2018
Microbial dysbiosis associated with impaired intestinal Na+/H+ exchange accelerates and exacerbates colitis in ex-germ free mice.
Mucosal immunology.
11(5):1329-1341
[DOI] 10.1038/s41385-018-0035-2.
[PMID] 29875400.
2018
Microbial networking in cancer: when two toxins collide.
British journal of cancer.
118(11):1407-1409
[DOI] 10.1038/s41416-018-0101-2.
[PMID] 29773837.
2018
Microbiota-Derived Metabolic Factors Reduce Campylobacteriosis in Mice.
Gastroenterology.
154(6):1751-1763.e2
[DOI] 10.1053/j.gastro.2018.01.042.
[PMID] 29408609.
2018
Precision medicine using microbiota.
Science (New York, N.Y.).
359(6371):32-34
[DOI] 10.1126/science.aar2946.
[PMID] 29302001.
2018
Transcription factor Bcl11b is central for Th2 cell differentiation in asthma and immune response to helminths
Nature Communications.
9(1)
2017
Cancer treatment: Bacterial snack attack deactivates a drug.
Nature.
550(7676):337-339
[DOI] 10.1038/550337a.
[PMID] 29052621.
2017
Carcinogenesis and therapeutics: the microbiota perspective.
Nature microbiology.
2
[DOI] 10.1038/nmicrobiol.2017.8.
[PMID] 28225000.
2017
ClbM is a versatile, cation-promiscuous MATE transporter found in the colibactin biosynthetic gene cluster.
Biochemical and biophysical research communications.
482(4):1233-1239
[DOI] 10.1016/j.bbrc.2016.12.018.
[PMID] 27939886.
2017
Human Intestinal Microbiota and Colorectal Cancer: Moving Beyond Associative Studies.
Gastroenterology.
153(6):1475-1478
[DOI] 10.1053/j.gastro.2017.10.030.
[PMID] 29100848.
2017
Locoregional Effects of Microbiota in a Preclinical Model of Colon Carcinogenesis.
Cancer research.
77(10):2620-2632
[DOI] 10.1158/0008-5472.CAN-16-3472.
[PMID] 28416491.
2017
Microbiota as a mediator of cancer progression and therapy.
Translational research : the journal of laboratory and clinical medicine.
179:139-154
[DOI] 10.1016/j.trsl.2016.07.021.
[PMID] 27554797.
2017
Novel insights into microbiome in colitis and colorectal cancer.
Current opinion in gastroenterology.
33(6):422-427
[DOI] 10.1097/MOG.0000000000000399.
[PMID] 28877044.
2017
Optimized multiplex immunofluorescence single-cell analysis reveals tuft cell heterogeneity.
JCI insight.
2(11)
[DOI] 10.1172/jci.insight.93487.
[PMID] 28570279.
2017
The Aryl Hydrocarbon Receptor Preferentially Marks and Promotes Gut Regulatory T Cells.
Cell reports.
21(8):2277-2290
[DOI] 10.1016/j.celrep.2017.10.114.
[PMID] 29166616.
2017
Workshop Report: Modulation of Antitumor Immune Responses by Dietary and Microbial Metabolites.
Journal of the National Cancer Institute.
109(6)
[DOI] 10.1093/jnci/djx040.
[PMID] 30053241.
2016
A Rapid Screenable Assay for Compounds That Protect Against Intestinal Injury in Zebrafish Larva.
Methods in molecular biology (Clifton, N.J.).
1422:281-93
[DOI] 10.1007/978-1-4939-3603-8_25.
[PMID] 27246041.
2016
Altered intestinal microbiota-host mitochondria crosstalk in new onset Crohn’s disease.
Nature communications.
7
[DOI] 10.1038/ncomms13419.
[PMID] 27876802.
2016
Gut Microbiota and a Selectively Bred Taste Phenotype: A Novel Model of Microbiome-Behavior Relationships.
Psychosomatic medicine.
78(5):610-9
[DOI] 10.1097/PSY.0000000000000318.
[PMID] 27035357.
2016
High purity galacto-oligosaccharides enhance specific Bifidobacterium species and their metabolic activity in the mouse gut microbiome.
Beneficial microbes.
7(2):247-64
[DOI] 10.3920/BM2015.0114.
[PMID] 26839072.
2016
Intestinal Microbiota in Inflammatory Bowel Disease and Carcinogenesis: Implication for Therapeutics
Clinical Pharmacology & Therapeutics.
99(6):585-587
[DOI] 10.1002/cpt.348.
[PMID] 26850686.
2016
Intestinal Microbiota in Inflammatory Bowel Disease and Carcinogenesis: Implication for Therapeutics.
Clinical pharmacology and therapeutics.
99(6):585-7
[DOI] 10.1002/cpt.348.
[PMID] 26850686.
2016
MATE transport of the E. coli-derived genotoxin colibactin.
Nature microbiology.
1
[DOI] 10.1038/nmicrobiol.2015.9.
[PMID] 27571755.
2016
Microbiota and host immune responses: a love-hate relationship.
Immunology.
147(1):1-10
[DOI] 10.1111/imm.12538.
[PMID] 26439191.
2016
Murine Model of Intestinal Ischemia-reperfusion Injury.
Journal of visualized experiments : JoVE.
(111)
[DOI] 10.3791/53881.
[PMID] 27213580.
2016
The Innate Immune Receptor NLRX1 Functions as a Tumor Suppressor by Reducing Colon Tumorigenesis and Key Tumor-Promoting Signals.
Cell reports.
14(11):2562-75
[DOI] 10.1016/j.celrep.2016.02.064.
[PMID] 26971998.
2015
Differential Relevance of NF-κB and JNK in the Pathophysiology of Hemorrhage/Resususcitation-Induced Liver Injury after Chronic Ethanol Feeding.
PloS one.
10(9)
[DOI] 10.1371/journal.pone.0137875.
[PMID] 26367181.
2015
Inflammasome-independent role of AIM2 in suppressing colon tumorigenesis via DNA-PK and Akt.
Nature medicine.
21(8):906-13
[DOI] 10.1038/nm.3908.
[PMID] 26107252.
2015
Microbial activities and intestinal homeostasis: A delicate balance between health and disease.
Cellular and molecular gastroenterology and hepatology.
1(1):28-40
[PMID] 25729763.
View on:
PubMed
2015
Partial depletion of the proinflammatory monocyte population is neuroprotective in the myenteric plexus but not in the basal ganglia in a MPTP mouse model of Parkinson’s disease.
Brain, behavior, and immunity.
46:154-67
[DOI] 10.1016/j.bbi.2015.01.009.
[PMID] 25637482.
2015
Professor Arlette Darfeuille-Michaud: the discovery of adherent-invasive Escherichia coli.
Journal of Crohn's & colitis.
9(5):373-5
[DOI] 10.1093/ecco-jcc/jjv044.
[PMID] 25759068.
2015
SCFAs Take a Toll En Route to Metabolic Syndrome.
Cell metabolism.
22(6):954-6
[DOI] 10.1016/j.cmet.2015.11.006.
[PMID] 26636491.
2015
The Microbiome and Cancer: Is the ‘Oncobiome’ Mirage Real?
Trends in cancer.
1(1):24-35
[PMID] 26568984.
View on:
PubMed
2015
The Role of Curcumin in Modulating Colonic Microbiota During Colitis and Colon Cancer Prevention.
Inflammatory bowel diseases.
21(11):2483-94
[DOI] 10.1097/MIB.0000000000000522.
[PMID] 26218141.
2014
Bugs and food: a recipe for cancer?
Cell metabolism.
20(6):937-8
[DOI] 10.1016/j.cmet.2014.11.010.
[PMID] 25470545.
2014
Chemotherapy, immunity and microbiota–a new triumvirate?
Nature medicine.
20(2):126-7
[DOI] 10.1038/nm.3473.
[PMID] 24504404.
2014
Chronic Ethanol Feeding Modulates Inflammatory Mediators, Activation Of Nuclear Factor-Κb, And Responsiveness To Endotoxin In Murine Kupffer Cells And Circulating Leukocytes.
Mediators of Inflammation.
2014
[DOI] 10.1155/2014/808695.
[PMID] 24623963.
2014
Commensal microbiota stimulate systemic neutrophil migration through induction of serum amyloid A.
Cellular microbiology.
16(7):1053-67
[DOI] 10.1111/cmi.12257.
[PMID] 24373309.
2014
Could a swimming creature inform us on intestinal diseases? Lessons from zebrafish.
Inflammatory bowel diseases.
20(5):956-66
[DOI] 10.1097/01.MIB.0000442923.85569.68.
[PMID] 24577115.
2014
Do bugs define cancer geography?
The Journal of experimental medicine.
211(3)
[DOI] 10.1084/jem.2113insight3.
[PMID] 24616475.
2014
From promotion to management: the wide impact of bacteria on cancer and its treatment.
BioEssays : news and reviews in molecular, cellular and developmental biology.
36(7):658-64
[DOI] 10.1002/bies.201400015.
[PMID] 24752750.
2014
Fusobacterium and Enterobacteriaceae: important players for CRC?
Immunology letters.
162(2 Pt A):54-61
[DOI] 10.1016/j.imlet.2014.05.014.
[PMID] 24972311.
2014
Glass Microparticulate Ingestion: An Unusual And Difficult-To-Diagnose Cause Of Chronic Abdominal Pain.
Acg Case Reports Journal.
1(3):137-9
[DOI] 10.14309/crj.2014.29.
[PMID] 26157853.
2014
GPR109a: the missing link between microbiome and good health?
Immunity.
40(1):8-10
[DOI] 10.1016/j.immuni.2013.12.009.
[PMID] 24439263.
2014
Gut commensal bacteria and regional Wnt gene expression in the proximal versus distal colon.
The American journal of pathology.
184(3):592-9
[DOI] 10.1016/j.ajpath.2013.11.029.
[PMID] 24418259.
2014
Lactobacillus Acidophilus Ncfm Affects Colonic Mucosal Opioid Receptor Expression In Patients With Functional Abdominal Pain – A Randomised Clinical Study.
Alimentary Pharmacology & Therapeutics.
40(2):200-7
[DOI] 10.1111/apt.12800.
[PMID] 24853043.
2014
Microbial genomic analysis reveals the essential role of inflammation in bacteria-induced colorectal cancer.
Nature communications.
5
[DOI] 10.1038/ncomms5724.
[PMID] 25182170.
2014
Microbial imbalance and intestinal pathologies: connections and contributions.
Disease models & mechanisms.
7(10):1131-42
[DOI] 10.1242/dmm.016428.
[PMID] 25256712.
2014
Microbial-derived butyrate: an oncometabolite or tumor-suppressive metabolite?
Cell host & microbe.
16(2):143-145
[DOI] 10.1016/j.chom.2014.07.011.
[PMID] 25121740.
2014
Nucleotide-binding oligomerization domain-containing protein 2 controls host response to Campylobacter jejuni in Il10-/- mice.
The Journal of infectious diseases.
210(7):1145-54
[DOI] 10.1093/infdis/jiu148.
[PMID] 24620022.
2014
Protective mucosal immunity mediated by epithelial CD1d and IL-10.
Nature.
509(7501):497-502
[DOI] 10.1038/nature13150.
[PMID] 24717441.
2014
The microbiota protects against ischemia/reperfusion-induced intestinal injury through nucleotide-binding oligomerization domain-containing protein 2 (NOD2) signaling.
The American journal of pathology.
184(11):2965-75
[DOI] 10.1016/j.ajpath.2014.07.014.
[PMID] 25204845.
2014
Time To Enlist Life-Saving, Gutsy Allies
New Scientist.
224(2992):28-29
2013
[Microbial dysbiosis, a new risk factor in colorectal cancer?].
Medecine sciences : M/S.
29(6-7):582-5
[DOI] 10.1051/medsci/2013296010.
[PMID] 23859512.
2013
Activation Of Nf-Κb After Chronic Ethanol Intake And Haemorrhagic Shock/Resuscitation In Mice.
British journal of pharmacology.
170(3):506-18
[DOI] 10.1111/bph.12224.
[PMID] 23646923.
2013
Challenges in IBD research: update on progress and prioritization of the CCFA’s research agenda.
Inflammatory bowel diseases.
19(4):677-82
[DOI] 10.1097/MIB.0b013e31828134b3.
[PMID] 23448796.
2013
Colorectal cancer: looking for answers in the microbiota.
Cancer discovery.
3(4):384-7
[DOI] 10.1158/2159-8290.CD-13-0042.
[PMID] 23580283.
2013
Diet, microbiome, and the intestinal epithelium: an essential triumvirate?
BioMed research international.
2013
[DOI] 10.1155/2013/425146.
[PMID] 23586037.
2013
Epithelial cell-specific MyD88 signaling mediates ischemia/reperfusion-induced intestinal injury independent of microbial status.
Inflammatory bowel diseases.
19(13):2857-66
[DOI] 10.1097/01.MIB.0000435445.96933.37.
[PMID] 24141713.
2013
Glafenine-induced intestinal injury in zebrafish is ameliorated by μ-opioid signaling via enhancement of Atf6-dependent cellular stress responses.
Disease models & mechanisms.
6(1):146-59
[DOI] 10.1242/dmm.009852.
[PMID] 22917923.
2013
Intestinal epithelial cell-derived μ-opioid signaling protects against ischemia reperfusion injury through PI3K signaling.
The American journal of pathology.
182(3):776-85
[DOI] 10.1016/j.ajpath.2012.11.021.
[PMID] 23291213.
2013
Microbial Influence On Colorectal Cancer
Digestive Diseases and Sciences.
58
2013
Neonatal Fc receptor expression in dendritic cells mediates protective immunity against colorectal cancer.
Immunity.
39(6):1095-107
[DOI] 10.1016/j.immuni.2013.11.003.
[PMID] 24290911.
2013
Oxymatrine prevents NF-κB nuclear translocation and ameliorates acute intestinal inflammation.
Scientific reports.
3
[DOI] 10.1038/srep01629.
[PMID] 23568217.
2013
Phosphatidylinositol 3-kinase-γ signaling promotes Campylobacter jejuni-induced colitis through neutrophil recruitment in mice.
Journal of immunology (Baltimore, Md. : 1950).
190(1):357-65
[DOI] 10.4049/jimmunol.1201825.
[PMID] 23180818.
2013
Stochastic changes over time and not founder effects drive cage effects in microbial community assembly in a mouse model.
The ISME journal.
7(11):2116-25
[DOI] 10.1038/ismej.2013.106.
[PMID] 23823492.
2013
The complex interplay between inflammation, the microbiota and colorectal cancer.
Gut microbes.
4(3):253-8
[DOI] 10.4161/gmic.24220.
[PMID] 23549517.
2013
The microbiome and cancer.
Nature reviews. Cancer.
13(11):800-12
[DOI] 10.1038/nrc3610.
[PMID] 24132111.
2013
VSL#3 probiotic modifies mucosal microbial composition but does not reduce colitis-associated colorectal cancer.
Scientific reports.
3
[DOI] 10.1038/srep02868.
[PMID] 24100376.
2012
A cell permeable peptide inhibitor of NFAT inhibits macrophage cytokine expression and ameliorates experimental colitis.
PloS one.
7(3)
[DOI] 10.1371/journal.pone.0034172.
[PMID] 22479554.
2012
Campylobacter jejuni induces colitis through activation of mammalian target of rapamycin signaling.
Gastroenterology.
142(1):86-95.e5
[DOI] 10.1053/j.gastro.2011.09.042.
[PMID] 21963787.
2012
Colorectal cancer: CRC–all about microbial products and barrier function?
Nature reviews. Gastroenterology & hepatology.
9(12):694-6
[DOI] 10.1038/nrgastro.2012.220.
[PMID] 23165234.
2012
Intestinal inflammation targets cancer-inducing activity of the microbiota.
Science (New York, N.Y.).
338(6103):120-3
[DOI] 10.1126/science.1224820.
[PMID] 22903521.
2012
Mouse background strain profoundly influences Paneth cell function and intestinal microbial composition.
PloS one.
7(2)
[DOI] 10.1371/journal.pone.0032403.
[PMID] 22384242.
2012
NLRP12 suppresses colon inflammation and tumorigenesis through the negative regulation of noncanonical NF-κB signaling.
Immunity.
36(5):742-54
[DOI] 10.1016/j.immuni.2012.03.012.
[PMID] 22503542.
2012
Probiotic bacteria produce conjugated linoleic acid locally in the gut that targets macrophage PPAR γ to suppress colitis.
PloS one.
7(2)
[DOI] 10.1371/journal.pone.0031238.
[PMID] 22363592.
2012
Retinal not systemic oxidative and inflammatory stress correlated with VEGF expression in rodent models of insulin resistance and diabetes.
Investigative ophthalmology & visual science.
53(13):8424-32
[DOI] 10.1167/iovs.12-10207.
[PMID] 23197686.
2012
The microbiota is essential for the generation of black tea theaflavins-derived metabolites.
PloS one.
7(12)
[DOI] 10.1371/journal.pone.0051001.
[PMID] 23227227.
2012
The short isoform of the CEACAM1 receptor in intestinal T cells regulates mucosal immunity and homeostasis via Tfh cell induction.
Immunity.
37(5):930-46
[DOI] 10.1016/j.immuni.2012.07.016.
[PMID] 23123061.
2012
Think small: zebrafish as a model system of human pathology.
Journal of biomedicine & biotechnology.
2012
[DOI] 10.1155/2012/817341.
[PMID] 22701308.
2012
Time dependency and topography of hepatic nuclear factor κB activation after hemorrhagic shock and resuscitation in mice.
Shock (Augusta, Ga.).
38(5):486-92
[DOI] 10.1097/SHK.0b013e3182699072.
[PMID] 22814290.
2011
Gut microbial diversity is reduced by the probiotic VSL#3 and correlates with decreased TNBS-induced colitis.
Inflammatory bowel diseases.
17(1):289-97
[DOI] 10.1002/ibd.21366.
[PMID] 20564535.
2011
Gut microbiota and probiotics in colon tumorigenesis.
Cancer letters.
309(2):119-27
[DOI] 10.1016/j.canlet.2011.06.004.
[PMID] 21741763.
2011
Microbial colonization induces dynamic temporal and spatial patterns of NF-κB activation in the zebrafish digestive tract.
Gastroenterology.
141(1):197-207
[DOI] 10.1053/j.gastro.2011.03.042.
[PMID] 21439961.
2011
Microbiota in chronic mucosal inflammation.
International journal of inflammation.
2010
[DOI] 10.4061/2010/395032.
[PMID] 21318187.
2011
Mu opioid signaling protects against acute murine intestinal injury in a manner involving Stat3 signaling.
The American journal of pathology.
179(2):673-83
[DOI] 10.1016/j.ajpath.2011.04.032.
[PMID] 21801866.
2011
PI3K-dependent GSK3ß(Ser9)-phosphorylation is implicated in the intestinal epithelial cell wound-healing response.
PloS one.
6(10)
[DOI] 10.1371/journal.pone.0026340.
[PMID] 22039465.
2011
Pretreatment with the probiotic VSL#3 delays transition from inflammation to dysplasia in a rat model of colitis-associated cancer.
American journal of physiology. Gastrointestinal and liver physiology.
301(6):G1004-13
[DOI] 10.1152/ajpgi.00167.2011.
[PMID] 21903764.
2011
Structural identification of mouse fecal metabolites of theaflavin 3,3′-digallate using liquid chromatography tandem mass spectrometry.
Journal of chromatography. A.
1218(41):7297-306
[DOI] 10.1016/j.chroma.2011.08.056.
[PMID] 21906744.
2011
The hydroxylase inhibitor dimethyloxallyl glycine attenuates endotoxic shock via alternative activation of macrophages and IL-10 production by B1 cells.
Shock (Augusta, Ga.).
36(3):295-302
[DOI] 10.1097/SHK.0b013e318225ad7e.
[PMID] 21844787.
2011
The struggle within: microbial influences on colorectal cancer.
Inflammatory bowel diseases.
17(1):396-409
[DOI] 10.1002/ibd.21354.
[PMID] 20848537.
2010
Alleviating cancer drug toxicity by inhibiting a bacterial enzyme.
Science (New York, N.Y.).
330(6005):831-5
[DOI] 10.1126/science.1191175.
[PMID] 21051639.
2010
Downregulation of aging-related Klotho gene in experimental colitis: the role of TNF and IFNGamma
Gastroenterology.
138(4):1384-1394
2010
High-fat diet: bacteria interactions promote intestinal inflammation which precedes and correlates with obesity and insulin resistance in mouse.
PloS one.
5(8)
[DOI] 10.1371/journal.pone.0012191.
[PMID] 20808947.
2010
MyD88 signaling in the intestine: Dr Jekyll and Mr Hyde?
Gastroenterology.
139(2):383-5
[DOI] 10.1053/j.gastro.2010.06.027.
[PMID] 20600062.
2010
Probiotics and ileitis: could augmentation of TNF/NFκB activity be the answer?
Gut microbes.
1(3):196-9
[DOI] 10.4161/gmic.1.3.12485.
[PMID] 21327025.
2010
The NLRP3 inflammasome functions as a negative regulator of tumorigenesis during colitis-associated cancer.
The Journal of experimental medicine.
207(5):1045-56
[DOI] 10.1084/jem.20100050.
[PMID] 20385749.
2010
Tumor necrosis factor and interferon-gamma down-regulate Klotho in mice with colitis.
Gastroenterology.
138(4):1384-94, 1394.e1
[DOI] 10.1053/j.gastro.2009.12.002.
[PMID] 20004202.
2009
Gnotobiotic IL-10; NF-kappaB mice develop rapid and severe colitis following Campylobacter jejuni infection.
PloS one.
4(10)
[DOI] 10.1371/journal.pone.0007413.
[PMID] 19841748.
2009
Intestinal epithelial-derived TAK1 signaling is essential for cytoprotection against chemical-induced colitis.
PloS one.
4(2)
[DOI] 10.1371/journal.pone.0004561.
[PMID] 19234607.
2009
Microbes and colorectal cancer: is there a relationship?
Current oncology (Toronto, Ont.).
16(4):22-4
[PMID] 19672421.
View on:
PubMed
2009
Modulation of the intestinal microbiota alters colitis-associated colorectal cancer susceptibility.
PloS one.
4(6)
[DOI] 10.1371/journal.pone.0006026.
[PMID] 19551144.
2009
Tomato lycopene extract prevents lipopolysaccharide-induced NF-kappaB signaling but worsens dextran sulfate sodium-induced colitis in NF-kappaBEGFP mice.
PloS one.
4(2)
[DOI] 10.1371/journal.pone.0004562.
[PMID] 19234608.
2009
Wound healing responses at the gastrointestinal epithelium: a close look at novel regulatory factors and investigative approaches.
Zeitschrift fur Gastroenterologie.
47(12):1221-9
[DOI] 10.1055/s-0028-1109766.
[PMID] 19960401.
2008
Enterocyte-derived TAK1 signaling prevents epithelium apoptosis and the development of ileitis and colitis.
Journal of immunology (Baltimore, Md. : 1950).
181(2):1143-52
[PMID] 18606667.
View on:
PubMed
2008
Impaired Bcl3 up-regulation leads to enhanced lipopolysaccharide-induced interleukin (IL)-23P19 gene expression in IL-10(-/-) mice.
The Journal of biological chemistry.
283(21):14182-9
[DOI] 10.1074/jbc.M709029200.
[PMID] 18375954.
2008
Interleukin-8 expression is regulated by histone deacetylases through the nuclear factor-kappaB pathway in breast cancer.
Molecular pharmacology.
74(5):1359-66
[DOI] 10.1124/mol.108.047332.
[PMID] 18669446.
2008
Limited Effects Of Dietary Curcumin On Th-1 Driven Colitis In Il-10 Deficient Mice Suggest An Il-10-Dependent Mechanism Of Protection.
American Journal of Physiology-Gastrointestinal and Liver Physiology.
295(5):G1079-91
[DOI] 10.1152/ajpgi.90365.2008.
[PMID] 18818316.
2008
Nf-kappa B signaling cascade and IBD: turn it down?
Inflammatory bowel diseases.
14 Suppl 2:S108-9
[DOI] 10.1002/ibd.20717.
[PMID] 18816651.
2008
NF-kappaB and the intestine: friend or foe?
Inflammatory bowel diseases.
14(1):114-24
[PMID] 17763472.
View on:
PubMed
2008
Regulation and functional impact of lipopolysaccharide induced Nod2 gene expression in the murine epididymal epithelial cell line PC1.
Immunology.
124(2):256-64
[DOI] 10.1111/j.1365-2567.2007.02763.x.
[PMID] 18284470.
2008
Toll-like receptor 9-dependent macrophage activation by Entamoeba histolytica DNA.
Infection and immunity.
76(1):289-97
[PMID] 17984204.
View on:
PubMed
2007
Amelioration of chronic murine colitis by peptide-mediated transduction of the IkappaB kinase inhibitor NEMO binding domain peptide.
Journal of immunology (Baltimore, Md. : 1950).
179(11):7852-9
[PMID] 18025231.
View on:
PubMed
2007
Dual-association of gnotobiotic IL-10-/- mice with 2 nonpathogenic commensal bacteria induces aggressive pancolitis.
Inflammatory bowel diseases.
13(12):1457-66
[PMID] 17763473.
View on:
PubMed
2007
Gnotobiotic IL-10-/-;NF-kappa B(EGFP) mice reveal the critical role of TLR/NF-kappa B signaling in commensal bacteria-induced colitis.
Journal of immunology (Baltimore, Md. : 1950).
178(10):6522-32
[PMID] 17475882.
View on:
PubMed
2007
The flavonoid luteolin worsens chemical-induced colitis in NF-kappaB(EGFP) transgenic mice through blockade of NF-kappaB-dependent protective molecules.
PloS one.
2(7)
[PMID] 17611628.
View on:
PubMed
2006
Critical role for H3 phosphorylation and p38-MAPK pathway in intestinal wound-healing response
American Journal of Physiology-Cell Physiology.
207(3):809-815
2006
Wound-induced p38MAPK-dependent histone H3 phosphorylation correlates with increased COX-2 expression in enterocytes.
Journal of cellular physiology.
207(3):809-15
[PMID] 16508963.
View on:
PubMed
2005
Activation of NF-kappaB following detachment delays apoptosis in intestinal epithelial cells.
Oncogene.
24(43):6482-91
[PMID] 16007176.
View on:
PubMed
2005
Adenosine is a negative regulator of NF-kappaB and MAPK signaling in human intestinal epithelial cells.
Cellular immunology.
237(2):86-95
[PMID] 16413516.
View on:
PubMed
2005
Inhibition of macrophage nuclear factor-kappaB leads to a dominant anti-inflammatory phenotype that attenuates glomerular inflammation in vivo.
The American journal of pathology.
167(1):27-37
[PMID] 15972949.
View on:
PubMed
2005
Regulation of TNF-related apoptosis-inducing ligand-mediated death-signal pathway in human beta cells by Fas-associated death domain and nuclear factor kappaB.
Human immunology.
66(7):799-809
[PMID] 16112027.
View on:
PubMed
2005
Salvia miltiorrhiza water-soluble extract, but not its constituent salvianolic acid B, abrogates LPS-induced NF-kappaB signalling in intestinal epithelial cells.
Clinical and experimental immunology.
141(2):288-97
[PMID] 15996193.
View on:
PubMed
2005
Serum amyloid A activates NF-kappaB and proinflammatory gene expression in human and murine intestinal epithelial cells.
European journal of immunology.
35(3):718-26
[PMID] 15724247.
View on:
PubMed
2005
STAT3 regulates NF-kappaB recruitment to the IL-12p40 promoter in dendritic cells.
Blood.
105(2):689-96
[PMID] 15251981.
View on:
PubMed
2005
The flavonoid luteolin prevents lipopolysaccharide-induced NF-kappaB signalling and gene expression by blocking IkappaB kinase activity in intestinal epithelial cells and bone-marrow derived dendritic cells.
Immunology.
115(3):375-87
[PMID] 15946255.
View on:
PubMed
2005
Tumor necrosis factor (TNF) alpha increases collagen accumulation and proliferation in intestinal myofibroblasts via TNF receptor 2.
The Journal of biological chemistry.
280(43):36099-109
[PMID] 16141211.
View on:
PubMed
2005
Ubiquitin protein modification and signal transduction: implications for inflammatory bowel diseases.
Inflammatory bowel diseases.
11(12):1097-107
[PMID] 16306773.
View on:
PubMed
2004
Differential effect of immune cells on non-pathogenic Gram-negative bacteria-induced nuclear factor-kappaB activation and pro-inflammatory gene expression in intestinal epithelial cells.
Immunology.
112(2):310-20
[PMID] 15147574.
View on:
PubMed
2004
Differential Effects Of Deoxycholic Acid And Taurodeoxycholic Acid On Nf-Kappa B Signal Transduction And Il-8 Gene Expression In Colonic Epithelial Cells.
American Journal of Physiology-Gastrointestinal and Liver Physiology.
286(6):G1000-8
[PMID] 14726307.
View on:
PubMed
2004
Down-regulation of MEK/ERK signaling by E-cadherin-dependent PI3K/Akt pathway in differentiating intestinal epithelial cells.
Journal of cellular physiology.
199(1):32-9
[PMID] 14978732.
View on:
PubMed
2004
In vivo pattern of lipopolysaccharide and anti-CD3-induced NF-kappa B activation using a novel gene-targeted enhanced GFP reporter gene mouse.
Journal of immunology (Baltimore, Md. : 1950).
173(3):1561-70
[PMID] 15265883.
View on:
PubMed
2004
Interaction between resident luminal bacteria and the host: can a healthy relationship turn sour?
Journal of pediatric gastroenterology and nutrition.
38(2):123-36
[PMID] 14734871.
View on:
PubMed
2004
Loss Of E-Cadherin Leads To Upregulation Of Nfkappab Activity In Malignant Melanoma.
Oncogene.
23(52):8509-19
[PMID] 15378016.
View on:
PubMed
2004
Nf-Kappab Inducing Kinase Activates Nf-Kappab Transcriptional Activity Independently Of Ikappab Kinase Gamma Through A P38 Mapk-Dependent Rela Phosphorylation Pathway.
Cellular Signalling.
16(9):1023-32
[PMID] 15212763.
View on:
PubMed
2004
NF-kappaB-inducing kinase restores defective IkappaB kinase activity and NF-kappaB signaling in intestinal epithelial cells.
Cellular signalling.
16(6):741-50
[PMID] 15093615.
View on:
PubMed
2004
Role of NF-kappaB in inflammatory disorders: just when you thought you knew everything!
Journal of pediatric gastroenterology and nutrition.
38(1):109-10
[PMID] 14733184.
View on:
PubMed
2003
Butyrate Modulates Intestinal Epithelial Cell-Mediated Neutrophil Migration.
Clinical and Experimental Immunology.
131(1):53-60
[DOI] 10.1046/j.1365-2249.2003.02056.x.
[PMID] 12519386.
2003
Intestinal epithelial cells and innate immunity in the intestine: is CARD15/Nod2 another player?
Gastroenterology.
124(4):1145-9
[PMID] 12671908.
View on:
PubMed
2003
Toll-like receptor 4 mediates inflammatory signaling by bacterial lipopolysaccharide in human hepatic stellate cells.
Hepatology (Baltimore, Md.).
37(5):1043-55
[PMID] 12717385.
View on:
PubMed
2003
Transforming growth factor-beta 1 inhibits non-pathogenic Gram negative bacteria-induced NF-kappa B recruitment to the interleukin-6 gene promoter in intestinal epithelial cells through modulation of histone acetylation.
The Journal of biological chemistry.
278(26):23851-60
[PMID] 12672795.
View on:
PubMed
2002
Constitutive nuclear factor-kappa B activity is required for central neuron survival.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
22(19):8466-75
[PMID] 12351721.
View on:
PubMed
2002
Differential requirement for NF-kappaB-inducing kinase in the induction of NF-kappaB by IL-1beta, TNF-alpha, and Fas.
American journal of physiology. Cell physiology.
283(1):C347-57
[PMID] 12055104.
View on:
PubMed
2002
IKK beta and phosphatidylinositol 3-kinase/Akt participate in non-pathogenic Gram-negative enteric bacteria-induced RelA phosphorylation and NF-kappa B activation in both primary and intestinal epithelial cell lines.
The Journal of biological chemistry.
277(41):38168-78
[PMID] 12140289.
View on:
PubMed
2001
Cryptosporidium Parvum Activates Nuclear Factor Kappab In Biliary Epithelia Preventing Epithelial Cell Apoptosis.
Gastroenterology.
120(7):1774-83
[PMID] 11375958.
View on:
PubMed
2001
Inhibition Of Cytokine-Induced Nf-Kappab Activation By Adenovirus-Mediated Expression Of A Nf-Kappab Super-Repressor Prevents Beta-Cell Apoptosis.
Diabetes.
50(10):2219-24
[PMID] 11574401.
View on:
PubMed
2001
Regulatory Role Of Phosphatidylinositol 3-Kinase On Tnf-Alpha-Induced Cyclooxygenase 2 Expression In Colonic Epithelial Cells.
Gastroenterology.
120(5):1117-27
[PMID] 11266376.
View on:
PubMed
2000
Cellular Differentiation Causes A Selective Down-Regulation Of Interleukin (Il)-1Beta-Mediated Nf-Kappab Activation And Il-8 Gene Expression In Intestinal Epithelial Cells.
Journal of Biological Chemistry.
275(16):12207-13
[PMID] 10766857.
View on:
PubMed
2000
Nf-Kappab Signaling Proteins As Therapeutic Targets For Inflammatory Bowel Diseases.
Inflammatory Bowel Diseases.
6(3):206-13
[PMID] 10961593.
View on:
PubMed
2000
The I Kappa B/Nf-Kappa B System: A Key Determinant Of Mucosalinflammation And Protection.
American journal of physiology. Cell physiology.
278(3):C451-62
[PMID] 10712233.
View on:
PubMed
1999
Curcumin blocks cytokine-mediated NF-kappa B activation and proinflammatory gene expression by inhibiting inhibitory factor I-kappa B kinase activity.
Journal of immunology (Baltimore, Md. : 1950).
163(6):3474-83
[PMID] 10477620.
View on:
PubMed
1999
Molecular And Cellular Biology Of The Small Intestine.
Current Opinion in Gastroenterology.
15(2):103-7
[PMID] 17023928.
View on:
PubMed
1999
Suppression of NF-kappaB-dependent proinflammatory gene expression in human RPE cells by a proteasome inhibitor.
Investigative ophthalmology & visual science.
40(2):477-86
[PMID] 9950608.
View on:
PubMed
1999
TNF receptor-associated factor-2 is involved in both IL-1 beta and TNF-alpha signaling cascades leading to NF-kappa B activation and IL-8 expression in human intestinal epithelial cells.
Journal of immunology (Baltimore, Md. : 1950).
162(8):4447-54
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PubMed
1998
Cytokines Induce Nf-Kappab In Activated But Not In Quiescent Rat Hepatic Stellate Cells.
American Journal of Physiology.
275(2 Pt 1):G269-78
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[PMID] 9688654.
1998
Differential Expression Of Interleukin 1 Receptor Antagonist Isoforms In Human Intestinal Epithelial Cells.
Gastroenterology.
115(6):1426-38
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PubMed
1998
Inhibition of NFkappaB in activated rat hepatic stellate cells by proteasome inhibitors and an IkappaB super-repressor.
Hepatology (Baltimore, Md.).
27(5):1285-95
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View on:
PubMed
1998
Inhibition Of Proinflammatory Molecule Production By Adenovirus-Mediated Expression Of A Nuclear Factor Kappab Super-Repressor In Human Intestinal Epithelial Cells.
Journal of immunology (Baltimore, Md. : 1950).
160(1):410-8
[PMID] 9551998.
View on:
PubMed
1998
Mediation By Nf-Kappa B Of Cytokine Induced Expression Of Intercellular Adhesion Molecule 1 (Icam-1) In An Intestinal Epithelial Cell Line, A Process Blocked By Proteasome Inhibitors.
Gut.
42(6):779-87
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[PMID] 9691914.
1998
Specific Nf-Kappab Blockade Selectively Inhibits Tumour Necrosis Factor-Alpha-Induced Cox-2 But Not Constitutive Cox-1 Gene Expression In Ht-29 Cells.
Immunology.
95(4):537-43
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[PMID] 9893042.
1997
Differential Effects Of Cell Density On 5-Lipoxygenase (5-Lo), Five-Lipoxygenase-Activating Protein (Flap) And Interleukin-1 Beta (Il-1 Beta) Expression In Human Neutrophils.
Inflammation.
21(2):235-50
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PubMed
1997
Evidence for altered regulation of I kappa B alpha degradation in human colonic epithelial cells.
Journal of immunology (Baltimore, Md. : 1950).
158(1):226-34
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View on:
PubMed
1991
Differential Synthesis Of 5-Lipoxygenase In Peripheral Blood And Synovial Fluid Neutrophils In Rheumatoid Arthritis.
Journal of immunology (Baltimore, Md. : 1950).
146(8):2701-7
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View on:
PubMed
Grants
Mar 2019
ACTIVE
Role of the microbiota in DNA methylation and CRC development
Role: Principal Investigator
Funding: CORIELL INSTITUTE FOR MEDICAL RESEARCH
via NATL INST OF HLTH NCI
Jan 2019
ACTIVE
Human milk metabolomics and microbe-host interactions associated with pediatric obesity
Role: Other
Funding: NATL INST OF HLTH NIDDK
Jul 2018
ACTIVE
Role of Bacteria in Colitis-Associated Colon Cancer
Role: Principal Investigator
Funding: NATL INST OF HLTH NIDDK
Jan 2018
ACTIVE
The role of the microbiome on pancreatic carcinogenesis in a murine model
Role: Other
Funding: AMER CANCER SOC
Dec 2017
– Feb 2019
Role of the microbiota in DNA methylation and CRC development
Role: Principal Investigator
Funding: TEMPLE UNIVERSITY
via NATL INST OF HLTH NCI
Dec 2017
ACTIVE
Chemical approaches toward the identification, functional analysis, and biosynthesis of small molecule cyclomodulin
Role: Principal Investigator
Funding: YALE UNIV
via NATL INST OF HLTH NCI
Oct 2016
– Sep 2018
Role of Gram negative bacterial lipopolysaccharide in CXCR4-mediated pancreatic carcinogenesis
Role: Faculty
Funding: ASSOC OF VA SURGEONS FOU
Aug 2016
ACTIVE
ACE2, Brain, Gut Dysbiosis in Pulmonary Hypertension
Role: Co-Investigator
Funding: NATL INST OF HLTH NHLBI
Jul 2016
– Jun 2019
Impact of host signaling on microbial activities in the development of colitis-associated colorectal cancer
Role: Other
Funding: CROHNS & COLITIS FOU OF AMERICA
Apr 2016
ACTIVE
Brain-Gut Microbiome-Immune Axis in Hypertension
Role: Project Manager
Funding: NATL INST OF HLTH NHLBI
Dec 2015
– Nov 2019
Mechanism by which H2S-producing bacteria influence development of colorectal cancer
Role: Principal Investigator
Funding: NATL INST OF HLTH NCI
Jul 2015
ACTIVE
Florida Academic Cancer Center Alliance Seed Grants
Role: Project Manager
Funding: UF HEALTH SHANDS HOSPITAL
Jun 2015
– Nov 2017
Microbial Factors Implicated in the Development of Colorectal Cancer
Role: Principal Investigator
Funding: UF DSR OPPORTUNITY FUND
Feb 2015
ACTIVE
UF Health Cancer Center Pilot Project Grants funded through the Florida Consortium of National Cancer Institute Centers Program
Role: Project Manager
Funding: UF HEALTH SHANDS HOSPITAL
Jan 2015
ACTIVE
Impact of microbiota-mediated biotransformation of black tea polyphenols on GI health
Role: Principal Investigator
Funding: NATL CTR FOR COMPLEM AND INTEGRATIVE HLT
May 2014
– May 2019
Multiple Sponsors
Role: Principal Investigator
Funding: MULTIPLE SPONSORS
Jul 2013
ACTIVE
Florida Center for Brain Tumor Research – Statewide Brain Tumor Registry Program at the McKnight Brain Institute
Role: Project Manager
Funding: FL DEPT OF HLTH
Jul 2013
– Mar 2018
Role of Bacteria in Colitis-Associated Colon Cancer
Role: Principal Investigator
Funding: NATL INST OF HLTH NIDDK
Jul 2013
– Jun 2016
Regulation of Immunosuppressive Molecules in IBD
Role: Principal Investigator
Funding: NATL INST OF HLTH NIDDK
Teaching Profile
Courses Taught
2018-2021
GMS6065 Fundamentals of Cancer Biology
2016-2019
GMS6001 Fundamentals of Biomedical Sciences I
2018
GMS7979 Advanced Research
2018
GMS7980 Research for Doctoral Dissertation
2013
VME6934 Topics in Veterinary Medical Sciences
Contact Details
Phones:
- Business:
- (352) 294-5148
Emails:
- Business:
- cjobin@ufl.edu