Rachel C Newsome

Rachel C Newsome,

Graduate Student

Department: MD-GASTROENTEROLOGY
Business Phone: (352) 294-8335
Business Email: rnewsome@ufl.edu

Accomplishments

Grinter Scholarship Award
2018-2021 · University of Florida
UF Health Cancer Center Research Day Predoctoral Poster Presentation Winner
2018 · University of Florida,
Ambassador Award
2014 · Howard Hughes Medical Institute Science for Life
Intramural Undergraduate Research Award
2012 · Howard Hughes Medical Institute Science for Life
Florida Bright Futures Scholarship
2011-2015 · University of Florida

Research Profile

My undergraduate research was done in the lab of Dr. Steven Bruner in the Department of Chemistry at the University of Florida, investigating the natural product biosynthesis of the colibactin pks gene cluster in E. coli, specifically focusing on the mechanistic enzymology of the multidrug and toxic compound extrusion protein ClbM. I worked in Dr. Christian Jobin’s lab as a lab technician from 2016 to 2018, and started as a graduate student in the Graduate Program in Biomedical Sciences in Fall 2018. My research currently focuses on host-microbe interactions in regards to inflammation and cancer. I use bacteria, mice and zebrafish models in conjunction with sequencing, gavage, injections, immunohistochemistry, and qPCR to study the immune response to intestinal microbes and the role of bacteria in colorectal cancer development.

Publications

2021
Gut Microbiota Dysbiosis Associated with Persistent Fatigue in Hematopoietic Cell Transplantation Survivors.
Transplantation and cellular therapy. [DOI] 10.1016/j.jtct.2021.02.017. [PMID] 33775619.
2020
Amending microbiota by targeting intestinal inflammation with TNF blockade attenuates development of colorectal cancer.
Nature cancer. 1(7):723-734 [DOI] 10.1038/s43018-020-0078-7. [PMID] 33768208.
2020
Baseline Gut Microbiota Composition Is Associated with Major Infections Early after Hematopoietic Cell Transplantation.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 26(11):2001-2010 [DOI] 10.1016/j.bbmt.2020.07.023. [PMID] 32717434.
2020
Human Colon Mucosal Biofilms and Murine Host Communicate via Altered mRNA and microRNA Expression during Cancer.
mSystems. 5(1) [DOI] 10.1128/mSystems.00451-19. [PMID] 31937674.
2020
Microbiome-Derived Liquid Biopsy: New Hope for Cancer Screening?
Clinical Chemistry. 67(3):463-465 [DOI] 10.1093/clinchem/hvaa240. [PMID] 33277898.
2019
Campylobacter jejuni promotes colorectal tumorigenesis through the action of cytolethal distending toxin.
Gut. 68(2):289-300 [DOI] 10.1136/gutjnl-2018-317200. [PMID] 30377189.
2019
Microbial Colonization Coordinates the Pathogenesis of a Klebsiella pneumoniae Infant Isolate.
Scientific reports. 9(1) [DOI] 10.1038/s41598-019-39887-8. [PMID] 30833613.
2018
Intestinal microbiota enhances pancreatic carcinogenesis in preclinical models.
Carcinogenesis. 39(8):1068-1078 [DOI] 10.1093/carcin/bgy073. [PMID] 29846515.
2017
ClbM is a versatile, cation-promiscuous MATE transporter found in the colibactin biosynthetic gene cluster.
Biochemical and biophysical research communications. 482(4):1233-1239 [DOI] 10.1016/j.bbrc.2016.12.018. [PMID] 27939886.
2016
MATE transport of the E. coli-derived genotoxin colibactin.
Nature microbiology. 1 [DOI] 10.1038/nmicrobiol.2015.9. [PMID] 27571755.

Education

PhD – Cancer Biology
2018-2020 · University of Florida
B.S.
2015 · University of Florida

Contact Details

Phones:
Business:
(352) 294-8335
Emails:
Business:
rnewsome@ufl.edu