Rachel C Newsome,
Postdoctoral Associate
Accomplishments
Medical Guild Research Competition Gold Medal
2023
·
The Medical Guild of the UF College of Medicine
UF Health Cancer Center Inaugural Cancer Researcher on the Rise
2023
·
UF Health Cancer Center
UF Health Cancer Center Research Day Predoctoral Poster Award Winner
2023
·
UF Health Cancer Center
UF Innovate Invention of the Year
2023
·
UF Innovate Standing InnOvation
Advancement to Candidacy Award
2021
·
UF Medical Guild
Predoctoral Award
2021
·
UF Health Cancer Center
Grinter Scholarship Award
2018-2021
·
University of Florida
UF Health Cancer Center Research Day Predoctoral Poster Presentation Winner
2018
·
University of Florida,
Ambassador Award
2014
·
Howard Hughes Medical Institute Science for Life
Intramural Undergraduate Research Award
2012
·
Howard Hughes Medical Institute Science for Life
Florida Bright Futures Scholarship
2011-2015
·
University of Florida
Research Profile
My undergraduate research was done in the lab of Dr. Steven Bruner in the Department of Chemistry at the University of Florida, investigating the natural product biosynthesis of the colibactin pks gene cluster in E. coli, specifically focusing on the mechanistic enzymology of the multidrug and toxic compound extrusion protein ClbM. I worked in Dr. Christian Jobin’s lab as a lab technician from 2016 to 2018, and started as a graduate student in the Graduate Program in Biomedical Sciences in Fall 2018 in the advanced concentrations of Cancer Biology and Clinical and Translational Science. My graduate research focuses on the role of the gut microbiota in cancer immunotherapy. I use specific pathogen free and germ free mouse and zebrafish models of cancer and inflammation, bacterial culturomics, flow cytometry, primary cell culture, histology/pathology, next-generation sequencing, and immune checkpoint therapies to dissect the role of specific bacterial products in driving anti-tumor synergy with anti-PD-1 therapy.
Publications
Academic Articles
2024
Metabolic immaturity and breastmilk bile acid metabolites are central determinants of heightened newborn vulnerability to norovirus diarrhea.
Cell host & microbe.
32(9):1488-1501.e5
[DOI] 10.1016/j.chom.2024.08.003.
[PMID] 39214086.
2023
Hematopoietic-specific heterozygous loss of Dnmt3a exacerbates colitis-associated colon cancer.
The Journal of experimental medicine.
220(11)
[DOI] 10.1084/jem.20230011.
[PMID] 37615936.
2023
Western diet influences on microbiome and carcinogenesis.
Seminars in immunology.
67
[DOI] 10.1016/j.smim.2023.101756.
[PMID] 37018910.
2022
Finding clues in unexpected places: detection of pancreatic cancer through the faecal microbiome.
Gut.
71(7):1247-1248
[DOI] 10.1136/gutjnl-2021-326710.
[PMID] 35260443.
2022
Interaction of bacterial genera associated with therapeutic response to immune checkpoint PD-1 blockade in a United States cohort.
Genome medicine.
14(1)
[DOI] 10.1186/s13073-022-01037-7.
[PMID] 35346337.
2022
Intestinal microbiota modulates pancreatic carcinogenesis through intratumoral natural killer cells.
Gut microbes.
14(1)
[DOI] 10.1080/19490976.2022.2112881.
[PMID] 35980869.
2022
The microbiome, gastrointestinal cancer, and immunotherapy.
Journal of gastroenterology and hepatology.
37(2):263-272
[DOI] 10.1111/jgh.15742.
[PMID] 34820895.
2021
Gut Microbiota Dysbiosis Associated with Persistent Fatigue in Hematopoietic Cell Transplantation Survivors.
Transplantation and cellular therapy.
27(6):498.e1-498.e8
[DOI] 10.1016/j.jtct.2021.02.017.
[PMID] 33775619.
2021
The gut microbiome of COVID-19 recovered patients returns to uninfected status in a minority-dominated United States cohort.
Gut microbes.
13(1):1-15
[DOI] 10.1080/19490976.2021.1926840.
[PMID] 34100340.
2020
Amending microbiota by targeting intestinal inflammation with TNF blockade attenuates development of colorectal cancer.
Nature cancer.
1(7):723-734
[DOI] 10.1038/s43018-020-0078-7.
[PMID] 33768208.
2020
Baseline Gut Microbiota Composition Is Associated with Major Infections Early after Hematopoietic Cell Transplantation.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation.
26(11):2001-2010
[DOI] 10.1016/j.bbmt.2020.07.023.
[PMID] 32717434.
2020
Human Colon Mucosal Biofilms and Murine Host Communicate via Altered mRNA and microRNA Expression during Cancer.
mSystems.
5(1)
[DOI] 10.1128/mSystems.00451-19.
[PMID] 31937674.
2020
Microbiome-Derived Liquid Biopsy: New Hope for Cancer Screening?
Clinical Chemistry.
67(3):463-465
[DOI] 10.1093/clinchem/hvaa240.
[PMID] 33277898.
2019
Campylobacter jejuni promotes colorectal tumorigenesis through the action of cytolethal distending toxin.
Gut.
68(2):289-300
[DOI] 10.1136/gutjnl-2018-317200.
[PMID] 30377189.
2019
Microbial Colonization Coordinates the Pathogenesis of a Klebsiella pneumoniae Infant Isolate.
Scientific reports.
9(1)
[DOI] 10.1038/s41598-019-39887-8.
[PMID] 30833613.
2018
Intestinal microbiota enhances pancreatic carcinogenesis in preclinical models.
Carcinogenesis.
39(8):1068-1078
[DOI] 10.1093/carcin/bgy073.
[PMID] 29846515.
2017
ClbM is a versatile, cation-promiscuous MATE transporter found in the colibactin biosynthetic gene cluster.
Biochemical and biophysical research communications.
482(4):1233-1239
[DOI] 10.1016/j.bbrc.2016.12.018.
[PMID] 27939886.
2016
MATE transport of the E. coli-derived genotoxin colibactin.
Nature microbiology.
1
[DOI] 10.1038/nmicrobiol.2015.9.
[PMID] 27571755.
Education
PhD – Cancer Biology and Clinical and Translational Science
2018-2023
·
University of Florida
B.S. in Biochemistry
2017
·
University of Florida
Contact Details
Phones:
- Business:
- (352) 273-9474
Emails:
- Business:
- rnewsome@ufl.edu
Addresses:
- Business Mailing:
-
PO Box 100214
GAINESVILLE FL 32610 - Business Street:
-
PO Box 100214
GAINESVILLE FL 32610