Ye Yang,

I am interested in understanding what/how host-microbe interactions influence host health and disease development. My Ph.D. study was on the regulation and function of alkaline phosphatase (ALP) genes in gut homeostasis and host responses to enteric pathogens using genetically manipulated zebrafish, mice and bacteria (Edwardsiella tarda).

I joined Dr. Christian Jobin’s lab in 2013 to study how host-microbe interactions impact intestinal pathologies (e.g., IBD, CRC, etc.) and how one can manipulate these interactions for better health. My research focuses on the interplay between host and colibactin-producing E. coli during colitis and tumor development. Using various model organisms (bacterium, zebrafish and mouse) and a range of techniques (molecular cloning, genome editing, sequencing, QPCR, in situ hybridization, immunochemistry, comet assay, microinjection, western blot, etc), I set to define the genetic elements and signaling pathways from both the host and microbe sides that contribute colitis and tumor development.

0000-0002-7576-3067