Ye Yang

Ye Yang

Assistant Scientist

Department: MD-GASTROENTEROLOGY
Business Phone: (352) 294-5112
Business Email: ye.yang@medicine.ufl.edu

Accomplishments

Research Fellowship Award
2016-2019 · Crohn’s & Colitis Foundation of America
William R. Sistrum Memorial Scholarship
2009 · University of Oregon
Cancer Federation Fellowship
2008 · University of Oregon
Outstanding Student Scholarship
2001-2005 · University of Science & Technology of China

Research Profile

I am interested in understanding what/how host-microbe interactions influence host health and disease development. My Ph.D. study was on the regulation and function of alkaline phosphatase (ALP) genes in gut homeostasis and host responses to enteric pathogens using genetically manipulated zebrafish, mice and bacteria (Edwardsiella tarda).

I joined Dr. Christian Jobin’s lab in 2013 to study how host-microbe interactions impact intestinal pathologies (e.g., IBD, CRC, etc.) and how one can manipulate these interactions for better health. My research focuses on the interplay between host and colibactin-producing E. coli during colitis and tumor development. Using various model organisms (bacterium, zebrafish and mouse) and a range of techniques (molecular cloning, genome editing, sequencing, QPCR, in situ hybridization, immunochemistry, comet assay, microinjection, western blot, etc), I set to define the genetic elements and signaling pathways from both the host and microbe sides that contribute colitis and tumor development.

Open Researcher and Contributor ID (ORCID)

0000-0002-7576-3067

Publications

2016
MATE transport of the E. coli-derived genotoxin colibactin.
Nature microbiology. 1 [DOI] 10.1038/nmicrobiol.2015.9. [PMID] 27571755.
2015
Professor Arlette Darfeuille-Michaud: the discovery of adherent-invasive Escherichia coli.
Journal of Crohn's & colitis. 9(5):373-5 [DOI] 10.1093/ecco-jcc/jjv044. [PMID] 25759068.
2014
Microbial imbalance and intestinal pathologies: connections and contributions.
Disease models & mechanisms. 7(10):1131-42 [DOI] 10.1242/dmm.016428. [PMID] 25256712.
2014
Could a swimming creature inform us on intestinal diseases? Lessons from zebrafish.
Inflammatory bowel diseases. 20(5):956-66 [DOI] 10.1097/01.MIB.0000442923.85569.68. [PMID] 24577115.

Grants

Jul 2016 – Jun 2019
Impact of host signaling on microbial activities in the development of colitis-associated colorectal cancer
Role: Principal Investigator
Funding: CROHNS & COLITIS FOU OF AMERICA

Education

PhD
2013 · University of Oregon
BSc
2005 · University of Science & Technology of China

Contact Details

Phones:
Business:
(352) 294-5112
Emails: