Ellen M Zimmermann

Ellen M Zimmermann, M.D.

Associate Dean & Professor

Department: MD-GASTROENTEROLOGY
Business Phone: (352) 273-9474
Business Email: ezimmer2@ufl.edu

Board Certifications

  • Gastroenterology
    American Board of Internal Medicine
  • Internal Medicine
    American Board of Internal Medicine

Clinical Profile

Specialties
  • Medicine
Subspecialties
  • Gastroenterology
Areas of Interest
  • Crohn disease
  • Ulcerative colitis

Publications

2021
Newly Diagnosed Patients with Inflammatory Bowel Disease: The Relationship Between Perceived Psychological Support, Health-Related Quality of Life, and Disease Activity.
Health equity. 5(1):42-48 [DOI] 10.1089/heq.2020.0053. [PMID] 33681688.
2020
Characteristics of Faculty at Risk of Leaving Their Medical Schools: An Analysis of the StandPoint™ Faculty Engagement Survey.
Journal of healthcare leadership. 12:1-10 [DOI] 10.2147/JHL.S225291. [PMID] 32021533.
2020
College Students with Inflammatory Bowel Disease: A Qualitative Study of Challenges Associated with College Transition and Self-Care.
Health equity. 4(1):190-197 [DOI] 10.1089/heq.2019.0053. [PMID] 32440616.
2020
Lipids and Lipid-Processing Pathways in Drug Delivery and Therapeutics.
International journal of molecular sciences. 21(9) [DOI] 10.3390/ijms21093248. [PMID] 32375338.
2020
Phospholipid Cyclosporine Prodrugs Targeted at Inflammatory Bowel Disease (IBD) Treatment: Design, Synthesis, and in Vitro Validation.
ChemMedChem. 15(17):1639-1644 [DOI] 10.1002/cmdc.202000317. [PMID] 32618133.
2019
How to Foster Academic Promotion and Career Advancement of Women in Gastroenterology.
Gastroenterology. 157(3):598-601 [DOI] 10.1053/j.gastro.2019.07.041. [PMID] 31374216.
2019
Lipidic prodrug approach for improved oral drug delivery and therapy.
Medicinal research reviews. 39(2):579-607 [DOI] 10.1002/med.21533. [PMID] 30320896.
2019
Molecular Modeling-Guided Design of Phospholipid-Based Prodrugs.
International journal of molecular sciences. 20(9) [DOI] 10.3390/ijms20092210. [PMID] 31060339.
2019
Phospholipid-Based Prodrugs for Colon-Targeted Drug Delivery: Experimental Study and In-Silico Simulations.
Pharmaceutics. 11(4) [DOI] 10.3390/pharmaceutics11040186. [PMID] 30995772.
2019
Pre-operative total parenteral nutrition improves post-operative outcomes in a subset of Crohn’s disease patients undergoing major abdominal surgery.
Gastroenterology report. 7(2):107-114 [DOI] 10.1093/gastro/goy033. [PMID] 30976423.
2019
Real-world Pattern of Biologic Use in Patients With Inflammatory Bowel Disease: Treatment Persistence, Switching, and Importance of Concurrent Immunosuppressive Therapy.
Inflammatory bowel diseases. 25(8):1417-1427 [DOI] 10.1093/ibd/izz001. [PMID] 30839057.
2019
Small bowel stricture is associated with abnormal motility on the cine MRI sequence in patients with Crohn’s disease.
European journal of radiology. 118:264-270 [DOI] 10.1016/j.ejrad.2019.08.001. [PMID] 31439253.
2019
Solitary ascending colon ulcer diagnosed as gastrointestinal CMV disease.
BMJ case reports. 12(2) [DOI] 10.1136/bcr-2018-226355. [PMID] 30739086.
2019
The prospects of lipidic prodrugs: an old approach with an emerging future.
Future medicinal chemistry. 11(19):2563-2571 [DOI] 10.4155/fmc-2019-0155. [PMID] 31633401.
2018
Consensus Recommendations for Evaluation, Interpretation, and Utilization of Computed Tomography and Magnetic Resonance Enterography in Patients With Small Bowel Crohn’s Disease.
Radiology. 286(3):776-799 [DOI] 10.1148/radiol.2018171737. [PMID] 29319414.
2018
Effective communication of cross-sectional imaging findings in Crohn’s disease: comparing conventional EMR reporting to a published scoring system.
Abdominal radiology (New York). 43(7):1798-1806 [DOI] 10.1007/s00261-017-1368-0. [PMID] 29075825.
2018
Effects of Preoperative Use of Biologic Agents on Operative Outcomes in Crohn’s Disease Patients.
The American surgeon. 84(9):1526-1530 [PMID] 30268188.
View on: PubMed
2018
Perioperative Care of Patients with Inflammatory Bowel Disease: Focus on Nutritional Support.
Gastroenterology research and practice. 2018 [DOI] 10.1155/2018/7890161. [PMID] 30344603.
2018
Prospects and Challenges of Phospholipid-Based Prodrugs.
Pharmaceutics. 10(4) [DOI] 10.3390/pharmaceutics10040210. [PMID] 30388756.
2018
What a medical school chair wants from the dean.
Journal of healthcare leadership. 10:33-44 [DOI] 10.2147/JHL.S158937. [PMID] 29872359.
2017
A Fixed Stricture on Routine Cross-Sectional Imaging Predicts Disease-Related Complications and Adverse Outcomes in Patients With Crohn’s Disease
Inflammatory Bowel Diseases. 23(4):641-649 [DOI] 10.1097/MIB.0000000000001054.
2017
A Fixed Stricture on Routine Cross-sectional Imaging Predicts Disease-Related Complications and Adverse Outcomes in Patients with Crohn’s Disease.
Inflammatory bowel diseases. 23(4):641-649 [DOI] 10.1097/MIB.0000000000001054. [PMID] 28267043.
2017
Computational modeling and in-vitro/in-silico correlation of phospholipid-based prodrugs for targeted drug delivery in inflammatory bowel disease.
Journal of computer-aided molecular design. 31(11):1021-1028 [DOI] 10.1007/s10822-017-0079-5. [PMID] 29101519.
2017
Phospholipid-drug conjugates as a novel oral drug targeting approach for the treatment of inflammatory bowel disease.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 108:78-85 [DOI] 10.1016/j.ejps.2017.06.022. [PMID] 28627471.
2016
Anti-TNFα alters the natural history of experimental Crohn’s disease in rats when begun early, but not late, in disease.
American journal of physiology. Gastrointestinal and liver physiology. 311(4):G688-G698 [DOI] 10.1152/ajpgi.00216.2015. [PMID] 27562059.
2016
Phospholipid-Based Prodrugs for Drug Targeting in Inflammatory Bowel Disease: Computational Optimization and In-Vitro Correlation.
Current topics in medicinal chemistry. 16(23):2543-8 [PMID] 27086789.
View on: PubMed
2015
Ct and Mr Enterography in Crohn’s Disease: Current and Future Applications
Abdominal Imaging. 40(5):965-974 [DOI] 10.1007/s00261-015-0360-9. [PMID] 25637127.
2015
CT and MR enterography in Crohn’s disease: current and future applications.
Abdominal imaging. 40(5):965-74 [DOI] 10.1007/s00261-015-0360-9. [PMID] 25637127.
2014
Effects of inflammatory bowel disease on students’ adjustment to college.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association. 12(12):2055-62.e1 [DOI] 10.1016/j.cgh.2014.03.032. [PMID] 24726907.
2014
Magnetization transfer in lamellar liquid crystals.
Magnetic resonance in medicine. 72(5):1427-34 [DOI] 10.1002/mrm.25034. [PMID] 24258798.
2014
Modern prodrug design for targeted oral drug delivery.
Molecules (Basel, Switzerland). 19(10):16489-505 [DOI] 10.3390/molecules191016489. [PMID] 25317578.
2014
MR imaging of the small bowel in Crohn disease.
Magnetic resonance imaging clinics of North America. 22(1):13-22 [DOI] 10.1016/j.mric.2013.09.001. [PMID] 24238129.
2014
Zimmermann EM Effects of inflammatory bowel disease on students’ adjustment to college
Clinical Gastroenterology and Hepatology. 12:2055-2062
2013
Anti-tumor necrosis factor α prevents bowel fibrosis assessed by messenger RNA, histology, and magnetization transfer MRI in rats with Crohn’s disease.
Inflammatory bowel diseases. 19(4):683-90 [DOI] 10.1097/MIB.0b013e3182802c32. [PMID] 23429466.
2013
Crohn’s disease complicated by strictures: a systematic review.
Gut. 62(7):1072-84 [DOI] 10.1136/gutjnl-2012-304353. [PMID] 23626373.
2013
Development of a peptidoglycan-polysaccharide murine model of Crohn’s disease: effect of genetic background.
Inflammatory bowel diseases. 19(6):1238-44 [DOI] 10.1097/MIB.0b013e31828132b4. [PMID] 23619717.
2013
Endothelial PAS domain protein 1 activates the inflammatory response in the intestinal epithelium to promote colitis in mice.
Gastroenterology. 145(4):831-41 [DOI] 10.1053/j.gastro.2013.07.010. [PMID] 23860500.
2013
The unfolded protein response and chemical chaperones reduce protein misfolding and colitis in mice.
Gastroenterology. 144(5):989-1000.e6 [DOI] 10.1053/j.gastro.2013.01.023. [PMID] 23336977.
2012
A new look at Crohn’s disease: novel imaging techniques.
Current opinion in gastroenterology. 28(4):334-40 [DOI] 10.1097/MOG.0b013e3283540705. [PMID] 22678451.
2012
Automatic vs semi-automatic global cardiac function assessment using 64-row CT.
The British journal of radiology. 85(1015):e243-53 [DOI] 10.1259/bjr/65747000. [PMID] 22045953.
2012
Computed tomography enterography findings correlate with tissue inflammation, not fibrosis in resected small bowel Crohn’s disease.
Inflammatory bowel diseases. 18(5):849-56 [DOI] 10.1002/ibd.21801. [PMID] 21710535.
2012
Hypoxia-inducible factor-2α activation promotes colorectal cancer progression by dysregulating iron homeostasis.
Cancer research. 72(9):2285-93 [DOI] 10.1158/0008-5472.CAN-11-3836. [PMID] 22419665.
2012
Resveratrol causes cell cycle arrest, decreased collagen synthesis, and apoptosis in rat intestinal smooth muscle cells.
American journal of physiology. Gastrointestinal and liver physiology. 302(3):G326-35 [DOI] 10.1152/ajpgi.00083.2011. [PMID] 22052016.
2012
Resveratrol has antiinflammatory and antifibrotic effects in the peptidoglycan-polysaccharide rat model of Crohn’s disease.
Inflammatory bowel diseases. 18(4):613-23 [DOI] 10.1002/ibd.21843. [PMID] 22431488.
2011
Choosing the right cross-sectional imaging technique: trading image quality for radiation risk.
Inflammatory bowel diseases. 17(5):1089-91 [DOI] 10.1002/ibd.21536. [PMID] 21484960.
2011
Magnetization transfer helps detect intestinal fibrosis in an animal model of Crohn disease.
Radiology. 259(1):127-35 [DOI] 10.1148/radiol.10091648. [PMID] 21324841.
2011
MRI of the small bowel in patients with Crohn’s disease.
Current opinion in gastroenterology. 27(2):132-8 [DOI] 10.1097/MOG.0b013e3283438e5d. [PMID] 21297471.
2010
Adenoviral transduction of enterocytes and M-cells using in vitro models based on Caco-2 cells: the coxsackievirus and adenovirus receptor (CAR) mediates both apical and basolateral transduction.
Molecular pharmaceutics. 7(3):619-29 [DOI] 10.1021/mp9001377. [PMID] 20235596.
2010
CT enterography of pediatric Crohn disease.
Pediatric radiology. 40(1):97-105 [DOI] 10.1007/s00247-009-1465-5. [PMID] 19936733.
2010
Detection of colonic inflammation with Fourier transform infrared spectroscopy using a flexible silver halide fiber.
Biomedical optics express. 1(3):1014-1025 [PMID] 21258526.
View on: PubMed
2010
Drug targeting strategies for the treatment of inflammatory bowel disease: a mechanistic update.
Expert review of clinical immunology. 6(4):543-50 [DOI] 10.1586/eci.10.30. [PMID] 20594127.
2008
College adjustment in University of Michigan students with Crohn’s and colitis.
Inflammatory bowel diseases. 14(9):1281-6 [DOI] 10.1002/ibd.20484. [PMID] 18512247.
2008
Identification of symptom domains in ulcerative colitis that occur frequently during flares and are responsive to changes in disease activity.
Health and quality of life outcomes. 6 [DOI] 10.1186/1477-7525-6-69. [PMID] 18803870.
2008
Transanal delivery of angiotensin converting enzyme inhibitor prevents colonic fibrosis in a mouse colitis model: development of a unique mode of treatment.
Surgery. 144(2):259-68 [DOI] 10.1016/j.surg.2008.03.043. [PMID] 18656634.
2007
Computed tomographic enterography adds information to clinical management in small bowel Crohn’s disease.
Inflammatory bowel diseases. 13(3):262-8 [PMID] 17206719.
View on: PubMed
2007
The quantitative validation of non-endoscopic disease activity indices in ulcerative colitis.
Alimentary pharmacology & therapeutics. 25(3):333-42 [PMID] 17269991.
View on: PubMed
2006
Pruritus as a leading symptom: clinical characteristics and quality of life in German and Ugandan patients.
The British journal of dermatology. 155(5):957-64 [PMID] 17034525.
View on: PubMed
2006
Restituting intestinal epithelial cells exhibit increased transducibility by adenoviral vectors.
The journal of gene medicine. 8(12):1379-92 [PMID] 17133338.
View on: PubMed
2005
Chimeric Ad5 vectors expressing the short fiber of Ad41 show reduced affinity for human intestinal epithelium.
Molecular pharmaceutics. 2(6):500-8 [PMID] 16323957.
View on: PubMed
2005
Increased transduction of human intestinal epithelial cells by adenoviral vectors in inflammatory bowel disease.
Inflammatory bowel diseases. 11(5):464-72 [PMID] 15867586.
View on: PubMed
2005
Is endoscopy necessary for the measurement of disease activity in ulcerative colitis?
The American journal of gastroenterology. 100(2):355-61 [PMID] 15667493.
View on: PubMed
2005
Liposomal formulations of inflammatory bowel disease drugs: local versus systemic drug delivery in a rat model.
Pharmaceutical research. 22(8):1320-30 [PMID] 16078142.
View on: PubMed
2005
Novel drug delivery strategies for the treatment of inflammatory bowel disease.
Expert opinion on drug delivery. 2(3):451-63 [PMID] 16296767.
View on: PubMed
2005
Patient defined dichotomous end points for remission and clinical improvement in ulcerative colitis.
Gut. 54(6):782-8 [PMID] 15888785.
View on: PubMed
2004
IGF-I increases IGFBP-5 and collagen 1(I) mRNAs by the MAPK pathway in rat intestinal smooth muscle cells
American Journal of Physiology. 286:G777-G783
2003
Expression of NOD2 in Paneth cells: a possible link to Crohn’s ileitis.
Gut. 52(11):1591-7 [PMID] 14570728.
View on: PubMed
2001
IGF-I and IGFBP-5 in Crohn’s disease
American Journal of Physiology. 280:G1022-G1029
2001
Insulin-like growth factor I and insulin-like growth factor binding protein 5 in Crohn’s disease.
American journal of physiology. Gastrointestinal and liver physiology. 280(5):G1022-9 [PMID] 11292612.
View on: PubMed
2000
Cell-specific localization of insulin-like growth factor binding protein mRNAs in rat liver.
American journal of physiology. Gastrointestinal and liver physiology. 278(3):G447-57 [PMID] 10712265.
View on: PubMed
2000
Cimetidine absorption and elimination in rat small intestine.
Drug metabolism and disposition: the biological fate of chemicals. 28(1):65-72 [PMID] 10611142.
View on: PubMed
2000
IGF-I and procollagen alpha1(I) are coexpressed in a subset of mesenchymal cells in active Crohn’s disease.
American journal of physiology. Gastrointestinal and liver physiology. 279(6):G1307-22 [PMID] 11093955.
View on: PubMed
1999
Intestinal metabolism and transport of 5-aminosalicylate.
Drug metabolism and disposition: the biological fate of chemicals. 27(4):479-85 [PMID] 10101143.
View on: PubMed
1999
Regulation of paracellular absorption of cimetidine and 5-aminosalicylate in rat intestine.
Pharmaceutical research. 16(11):1781-5 [PMID] 10571287.
View on: PubMed
1998
Nonviral vector-mediated thymidine kinase gene transfer and ganciclovir treatment in leiomyoma cells.
Obstetrics and gynecology. 91(5 Pt 1):735-40 [PMID] 9572221.
View on: PubMed
1997
Cloning of a novel seven transmembrane receptor highly expressed in spleen and testes
Genomics. 42(3):462-466
1997
IGF-I induces collagen and IGFBP-5 mRNA in rat intestinal smooth muscle.
The American journal of physiology. 273(4):G875-82 [DOI] 10.1152/ajpgi.1997.273.4.G875. [PMID] 9357830.
1997
Substance P as a mediator of colonic secretory reflexes
American Journal of Physiology. 272:G238-G245
1994
Expression of insulin-like growth factor binding protein-4 and -5 mRNAs in adult rat forebrain.
The Journal of comparative neurology. 339(1):91-105 [PMID] 7508953.
View on: PubMed
1994
Tissue interleukin 1 and interleukin-1 receptor antagonist expression in enterocolitis in resistant and susceptible rats.
Gastroenterology. 106(4):960-72 [PMID] 8144001.
View on: PubMed
1993
Enhanced growth of small bowel in transgenic mice overexpressing bovine growth hormone.
Gastroenterology. 104(4):973-80 [PMID] 7681797.
View on: PubMed
1993
Insulinlike growth factor I and interleukin 1 beta messenger RNA in a rat model of granulomatous enterocolitis and hepatitis.
Gastroenterology. 105(2):399-409 [PMID] 8335195.
View on: PubMed
1986
Demonstration of thyrotropin-releasing hormone immunoreactivity in neurons of the mouse spinal dorsal horn
The Journal of Neuroscience. 6:1194-1197
1982
Effect of immuno-therapy on immunoglobulin E and immunoglobulin G antibodies to ragweed antigens: a six year prospective study
Journal of Allergy and Clinical Immunology. 70:261-271
1981
[The excessive mortality of the male sex].
Medizinische Klinik. 76(26):729-33 [PMID] 7198715.
View on: PubMed
1981
Immuno-therapy with short ragweed fraction A:D-glutamic acid: D-lysine polymer in ragweed hayfever
Journal of Allergy and Clinical Immunology. 67:272-278
1981
Measurement of IgG blocking antibodies by interference in the radioallergosorbent test
Journal of Immunology. 126:575-579
1981
Preseasonal intranasal immunotherapy with nebulized short ragweed extract
Journal of Allergy and Clinical Immunology. 67:237-242
1980
Interference in ragweed pollen and honeybee venom radioallergosorbent tests
Journal of Allergy and Clinical Immunology. 66:386-393

Grants

Apr 2021 ACTIVE
College-aged patients with Inflammatory Bowel Disease (IBD); addressing unique needs and improving disease outcomes.
Role: Principal Investigator
Funding: ARENA PHARMACEUTICALS
Dec 2020 ACTIVE
Project ECHO IBD
Role: Co-Investigator
Funding: PFIZER INC
May 2020 ACTIVE
SBIR – A Novel Immunological Probiotic for Treating Inflammatory Bowel Disease.
Role: Co-Investigator
Funding: RISE THERAPEUTICS via NATL INST OF HLTH NIDDK
Apr 2019 ACTIVE
A Novel Probiotic Engineered for Enhanced Immunological Function for Treating Inflammatory Bowel Disease
Role: Principal Investigator
Funding: RISE THERAPEUTICS via NATL INST OF HLTH NIAID
Jul 2018 – Jun 2019
A Novel Immunological Probiotic for Treating Inflammatory Bowel Disease
Role: Principal Investigator
Funding: RISE THERAPEUTICS via NATL INST OF HLTH NIDDK
Jan 2017 ACTIVE
Drug targeting strategy for the treatment of inflammatory bowel disease a novel prodrug approach
Role: Principal Investigator
Funding: US ISRAEL BINATIONAL SCI FOU
Jun 2016 – May 2018
College Students with Inflammatory Bowel Disease: Supporting the Transition to Adult IBD care
Role: Principal Investigator
Funding: ABBVIE

Education

Research Fellowship
1992 · University of North Carolina at Chapel Hill
Fellowship
1990 · University of Michigan Medical Center
Residency
1987 · University of Wisconsin Hospitals and Clinics
Internship
1985 · University of Wisconsin Hospitals and Clinics
M.D.
1984 · University of Wisconsin

Teaching Profile

Courses Taught
2020
BMS6634 GI and Hepatology

Contact Details

Phones:
Business:
(352) 273-9474
Emails:
Business:
ezimmer2@ufl.edu